ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Global features of neural activity in the olfactory system form a parallel code that predicts olfactory behavior and perception.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Integrating olfactory assessments in consciousness disorders: methodologies and therapeutic potential.Frontiers in neurology · 2026Review
- Shapley Fields Reveal Chemotopic Organization in the Mouse Olfactory Bulb Across Diverse Chemical Feature Sets.bioRxiv : the preprint server for biology · 2025Article
- Survey of temporal coding of sensory information.Frontiers in computational neuroscience · 2025Article
- The primacy model and the structure of olfactory space.PLoS computational biology · 2024Article
- A deep position-encoding model for predicting olfactory perception from molecular structures and electrostatics.NPJ systems biology and applications · 2024Article
- A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans.PLoS biology · 2024Article
- An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence inbioRxiv : the preprint server for biology · 2024Article
- Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila.Nature communications · 2023Article
- Neural manifolds for odor-driven innate and acquired appetitive preferences.Nature communications · 2023Article
- Olfactory abstraction: a communicative and metacognitive account.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
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- The perception of odor pleasantness is shared across cultures.Current biology : CB · 2022Article
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- Deconstructing the mouse olfactory percept through an ethological atlas.Current biology : CB · 2021Article
- Do all mice smell the same? Chemosensory cues from inbred and wild mouse strains elicit stereotypic sensory representations in the accessory olfactory bulb.BMC biology · 2021Article
- Odor hedonics coding in the vertebrate olfactory bulb.Cell and tissue research · 2021Review
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- Genetic variation across the human olfactory receptor repertoire alters odor perception.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Pleasantness and trigeminal sensations as salient dimensions in organizing the semantic and physiological spaces of odors.Scientific reports · 2018Article
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8 authors.
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Abstract
Odor identity is coded in spatiotemporal patterns of neural activity in the olfactory bulb. Here we asked whether meaningful olfactory information could also be read from the global olfactory neural population response. We applied standard statistical methods of dimensionality-reduction to neural activity from 12 previously published studies using seven different species. Four studies reported olfactory receptor activity, seven reported glomerulus activity, and one reported the activity of projection-neurons. We found two linear axes of neural population activity that accounted for more than half of the variance in neural response across species. The first axis was correlated with the total sum of odor-induced neural activity, and reflected the behavior of approach or withdrawal in animals, and odorant pleasantness in humans. The second and orthogonal axis reflected odorant toxicity across species. We conclude that in parallel with spatiotemporal pattern coding, the olfactory system can use simple global computations to read vital olfactory information from the neural population response.
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