ArticleJournal of virology2010
Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Novel Aspects of the Physiology of Pregnancy in Domestic Ruminants.Animals : an open access journal from MDPI · 2025Review
- A genome-wide study of ruminants uncovers two endogenous retrovirus families recently active in goats.Mobile DNA · 2025Article
- Ruminant conceptus-maternal interactions: interferon-tau and beyond.Journal of animal science · 2022Review
- Transposable elements shape the evolution of mammalian development.Nature reviews. Genetics · 2021Review
- Emerging Role of Extracellular Vesicles in Embryo-Maternal Communication throughout Implantation Processes.International journal of molecular sciences · 2020Review
- Extracellular vesicles: Novel regulators of conceptus-uterine interactions?Theriogenology · 2020Review
- 'Conceptualizing' the Endometrium: Identification of Conceptus-Derived Proteins During Early Pregnancy in Cattle.Biology of reproduction · 2015Article
- Retroviral envelope gene captures and syncytin exaptation for placentation in marsupials.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions.Journal of virology · 2015Article
- "Ménage à Trois": the evolutionary interplay between JSRV, enJSRVs and domestic sheep.Viruses · 2014Review
- Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol.Journal of animal science and biotechnology · 2014Review
- Extracellular vesicles in luminal fluid of the ovine uterus.PloS one · 2014Article
- Retroviruses facilitate the rapid evolution of the mammalian placenta.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Application of next generation sequencing in mammalian embryogenomics: lessons learned from endogenous betaretroviruses of sheep.Animal reproduction science · 2012Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
The sheep genome contains multiple copies of endogenous betaretroviruses highly related to the exogenous and oncogenic jaagsiekte sheep retrovirus (JSRV). The endogenous JSRVs (enJSRVs) are abundantly expressed in the uterine luminal and glandular epithelia as well as in the conceptus trophectoderm and are essential for conceptus elongation and trophectoderm growth and development. Of note, enJSRVs are present in sheep and goats but not cattle. At least 5 of the 27 enJSRV loci cloned to date possess an intact genomic organization and are able to produce viral particles in vitro. In this study, we found that enJSRVs form viral particles that are released into the uterine lumen of sheep. In order to test the infectious potential of enJSRV particles in the uterus, we transferred bovine blastocysts into synchronized ovine recipients and allowed them to develop for 13 days. Analysis of microdissected trophectoderm of the bovine conceptuses revealed the presence of enJSRV RNA and, in some cases, DNA. Interestingly, we found that RNAs belonging to only the most recently integrated enJSRV loci were packaged into viral particles and transmitted to the trophectoderm. Collectively, these results support the hypothesis that intact enJSRV loci expressed in the uterine endometrial epithelia are shed into the uterine lumen and could potentially transduce the conceptus trophectoderm. The essential role played by enJSRVs in sheep reproductive biology could also be played by endometrium-derived viral particles that influence development and differentiation of the trophectoderm.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.