ArticleClinical and vaccine immunology : CVI2010
Association of single nucleotide polymorphisms in cytotoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians.
Article in Clinical and vaccine immunology : CVI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Associations between cytotoxic T-lymphocyte-associated antigen 4 gene polymorphisms and diabetes mellitus: a meta-analysis of 76 case-control studies.Bioscience reports · 2019Pooled it
- Pooled it
- Article
- Association between CTLA-4 gene polymorphisms and Type 1 diabetes in Kurdish patients.Frontiers in endocrinology · 2026Article
- Association of Cytotoxic T-Lymphocyte Antigen-4 Gene Polymorphism with Type 1 Diabetes Mellitus: In silico Analysis of Biological Features of CTLA-4 Protein on Ethiopian Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients.Journal, genetic engineering & biotechnology · 2021Article
- CTLA-4 (+49A/G) Polymorphism in Type 1 Diabetes Children of Sudanese Population.Global medical genetics · 2021Article
- Identification of susceptibility SNPs in CTLA-4 and PTPN22 for scleritis in Han Chinese.Clinical and experimental immunology · 2019Article
- The synergic effects of CTLA-4/Foxp3-related genotypes and chromosomal aberrations on the risk of recurrent spontaneous abortion among a Chinese Han population.Journal of human genetics · 2018Article
- Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries.Current diabetes reports · 2016Review
- Association of theBiomedical reports · 2015Article
- Ctla-4 expression and polymorphisms in lung tissue of patients with diagnosed non-small-cell lung cancer.BioMed research international · 2013Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to HLA and insulin genes, the costimulatory molecule CTLA-4 gene is a confirmed type 1 diabetes (T1D) susceptibility gene. Previous studies investigated the association of CTLA-4 genetic variants with the risk of T1D, but with inconclusive findings. Here, we tested the contributions of common CTLA-4 gene variants to T1D susceptibility in Tunisian patients and control subjects. The study subjects comprised 228 T1D patients (47.8% females) and 193 unrelated healthy controls (45.6% females). Genotyping for CTLA-4 CT60A/G (rs3087243), +49A/G (rs231775), and -318C/T (rs5742909) was performed by PCR-restriction fragment length polymorphism (RFLP) analysis. The minor-allele frequencies (MAF) for the three CTLA-4 variants were significantly higher in T1D patients, and significantly higher frequencies of homozygous +49G/G and homozygous CT60G/G genotypes were seen in patients, which was confirmed by univariate regression analysis (taking the homozygous wild type as a reference). Of the eight possible three-locus CTLA-4 haplotypes (+49A/G, -318C/T, and CT60A/G) identified, multivariate regression analysis confirmed the positive association of ACG (odds ratio [OR], 1.93; 95% confidence interval [CI], 1.26 to 2.94), GCG (OR, 2.40; 95% CI, 1.11 to 5.21), and GTA (OR, 4.67; 95% CI, 1.52 to 14.39) haplotypes with T1D, after confounding variables were adjusted for. Our results indicate that CTLA-4 gene variants are associated with increased T1D susceptibility in Tunisian patients, further supporting a central role for altered T-cell costimulation in T1D pathogenesis.
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