ArticleThe Journal of clinical endocrinology and metabolism2010
Approach to the patient with resistance to thyroid hormone and pregnancy.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- 2024 European Thyroid Association Guidelines on diagnosis and management of genetic disorders of thyroid hormone transport, metabolism and action.European thyroid journal · 2024Guideline
- Thyroid dysfunction in Iranian pregnant women: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2020Pooled it
- A case of thyroid hormone resistance with thyroid regrowth: implications of misdiagnosis on patient care.JCEM case reports · 2026Article
- A Case of Thyroid Hormone Resistance Syndrome with a Novel Mutation (c.947G>a) in theInternational medical case reports journal · 2024Article
- R243W Mutation in Thyroid Hormone Resistance Syndrome Beta: A Case Report.Journal of the ASEAN Federation of Endocrine Societies · 2024Article
- Maternal Resistance to Thyroid Hormone β and Pregnancy Outcomes.The Journal of clinical endocrinology and metabolism · 2023Article
- The Relationship Between FetalThyroid : official journal of the American Thyroid Association · 2023Article
- A novel variant of THRβ and its 4-year clinical course in a Korean boy with resistance to thyroid hormone.Annals of pediatric endocrinology & metabolism · 2023Article
- Central TSH Dysregulation in a Patient with Familial Non-Autoimmune Autosomal Dominant Hyperthyroidism Due to a Novel Thyroid-Stimulating Hormone Receptor Disease-Causing Variant.Medicina (Kaunas, Lithuania) · 2021Article
- Thyroid Hormone Receptor α Mutations Cause Heart Defects in Zebrafish.Thyroid : official journal of the American Thyroid Association · 2021Article
- Resistance to Thyroid Hormone Beta: A Focused Review.Frontiers in endocrinology · 2021Review
- Thyroid hormone resistance from newborns to adults: a Spanish experience.Journal of endocrinological investigation · 2019Article
- Article
- Genomic test ends a long diagnostic odyssey in a patient with resistance to thyroid hormones.Thyroid research · 2019Article
- Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature.BMC pregnancy and childbirth · 2018Review
- Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies.Journal of clinical & translational endocrinology · 2018Review
- Prenatal Diagnosis of Resistance to Thyroid Hormone and Its Clinical Implications.The Journal of clinical endocrinology and metabolism · 2017Article
- Role of Thyroid Hormones in Skeletal Development and Bone Maintenance.Endocrine reviews · 2016Review
- Resistance to thyroid hormone--an incidental finding.BMJ case reports · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Resistance to thyroid hormone (RTH), a syndrome of reduced end-organ responsiveness to thyroid hormone (TH), is mostly caused by mutations in the TH receptor (TR) beta gene. Diagnosis is based on persistent elevations of serum free T(4) and often T(3) levels in the absence of TSH suppression, and confirmation in most cases is by way of genetic testing. The mainstay in the management of RTH patients who are asymptomatic is to recognize the correct diagnosis and avoid antithyroid treatment. Deciding whether to manage these patients with TH replacement is made even more challenging when an affected individual is pregnant. How one approaches such a patient with pregnancy and RTH would depend on the genotype of the fetus. This requires obtaining prenatal information on the genotype of the fetus and a thorough history of the outcome of previous pregnancies as well as a history of the course and outcome of other family members with RTH. If the TRbeta mutation is known in the mother, the fetus can be rapidly genotyped from DNA from amniocentesis for the same mutation, and then management decisions could be made regarding thyroid or antithyroid hormone treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.