ReviewCold Spring Harbor perspectives in biology2010
Chromatin remodeling in mammary gland differentiation and breast tumorigenesis.
Review in Cold Spring Harbor perspectives in biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health.Epigenetics · 2024Article
- Epigenetics in Inflammatory Breast Cancer: Biological Features and Therapeutic Perspectives.Cells · 2020Review
- Article
- Epigenetic Mechanisms of Tamoxifen Resistance in Luminal Breast Cancer.Diseases (Basel, Switzerland) · 2017Review
- Common stemness regulators of embryonic and cancer stem cells.World journal of stem cells · 2015Review
- DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.Nature communications · 2015Article
- Exposures to synthetic estrogens at different times during the life, and their effect on breast cancer risk.Journal of mammary gland biology and neoplasia · 2013Review
- Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives.International journal of molecular sciences · 2012Review
- Keeping an open mind: highlights and controversies of the breast cancer stem cell theory.Breast cancer (Dove Medical Press) · 2012Review
- Epigenome-Wide Association Studies (EWAS) in Cancer.Current genomics · 2012Article
- On chromatin remodeling in mammary gland differentiation and breast tumorigenesis.Cold Spring Harbor perspectives in biology · 2012Review
- Article
- High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring.Nature communications · 2012Article
- Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing.Nucleic acids research · 2011Article
- MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality.Molecular cancer · 2011Review
- An overview of epigenetics and chemoprevention.FEBS letters · 2011Review
- EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells.Breast cancer research : BCR · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
DNA methylation and histone modifications have essential roles in remodeling chromatin structure of genes necessary for multi-lineage differentiation of mammary stem/progenitor cells. The role of this well-defined epigenetic programming is to heritably maintain transcriptional plasticity of these loci over multiple cell divisions in the differentiated progeny. Epigenetic events can be deregulated in progenitor cells chronically exposed to xenoestrogen or inflammatory microenvironment. In addition, epigenetically mediated silencing of genes associated with tumor suppression can take place, resulting in clonal proliferation of undifferentiated or semidifferentiated cells. Alternatively, microRNAs that negatively regulate the expression of their protein-coding targets may become epigenetically repressed, leading to oncogenic expression of these genes. Here we further discuss interactions between DNA methylation and histone modifications that have significant contributions to the differentiation of mammary stem/progenitor cells and to tumor initiation and progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.