ArticleGenetics2010
Accidental amplification and inactivation of a methyltransferase gene eliminates cytosine methylation in Mycosphaerella graminicola.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- 5mC and 6mA DNA Methylation in the Fungal Kingdom: From Genome Defense to Epigenetic Regulation.Epigenomes · 2026Review
- Fungi as models of centromere innovation: from DNA sequence to 3-dimensional arrangement.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Review
- Recent reactivation of a pathogenicity-associated transposable element is associated with major chromosomal rearrangements in a fungal wheat pathogen.Nucleic acids research · 2024Article
- A systematic screen for co-option of transposable elements across the fungal kingdom.Mobile DNA · 2024Article
- A thousand-genome panel retraces the global spread and adaptation of a major fungal crop pathogen.Nature communications · 2023Article
- Recent transposable element bursts are associated with the proximity to genes in a fungal plant pathogen.PLoS pathogens · 2023Article
- Dynamics of transposable elements in recently diverged fungal pathogens: lineage-specific transposable element content and efficiency of genome defenses.G3 (Bethesda, Md.) · 2021Article
- Recent loss of the Dim2 DNA methyltransferase decreases mutation rate in repeats and changes evolutionary trajectory in a fungal pathogen.PLoS genetics · 2021Article
- Article
- Genome-Wide Analyses of Repeat-Induced Point Mutations in the Ascomycota.Frontiers in microbiology · 2020Article
- Variable genome evolution in fungi after transposon-mediated amplification of a housekeeping gene.Mobile DNA · 2019Article
- Article
- Evolution and genome architecture in fungal plant pathogens.Nature reviews. Microbiology · 2017Review
- RNA-seq-Based Gene Annotation and Comparative Genomics of Four Fungal Grass Pathogens in the Genus Zymoseptoria Identify Novel Orphan Genes and Species-Specific Invasions of Transposable Elements.G3 (Bethesda, Md.) · 2015Article
- Genome-wide profiling of DNA methylation provides insights into epigenetic regulation of fungal development in a plant pathogenic fungus, Magnaporthe oryzae.Scientific reports · 2015Article
- Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes.Epigenetics & chromatin · 2015Article
- The landscape of transposable elements in the finished genome of the fungal wheat pathogen Mycosphaerella graminicola.BMC genomics · 2014Article
- Reverse transcriptase and intron number evolution.Stem cell investigation · 2014Article
- Is the fungus Magnaporthe losing DNA methylation?Genetics · 2013Article
- Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A de novo search for repetitive elements in the genome sequence of the wheat pathogen Mycosphaerella graminicola identified a family of repeats containing a DNA cytosine methyltransferase sequence (MgDNMT). All 23 MgDNMT sequences identified carried signatures of repeat induced point mutation (RIP). All copies were subtelomeric in location except for one on chromosome 6. Synteny with M. fijiensis implied that the nontelomeric copy on chromosome 6 served as a template for subsequent amplifications. Southern analysis revealed that the MgDNMT sequence also was amplified in 15 additional M. graminicola isolates from various geographical regions. However, this amplification event was specific to M. graminicola; a search for MgDNMT homologs identified only a single, unmutated copy in the genomes of 11 other ascomycetes. A genome-wide methylation assay revealed that M. graminicola lacks cytosine methylation, as expected if its MgDNMT gene is inactivated. Methylation was present in several other species tested, including the closest known relatives of M. graminicola, species S1 and S2. Therefore, the observed changes most likely occurred within the past 10,500 years since the divergence between M. graminicola and S1. Our data indicate that the recent amplification of a single-copy MgDNMT gene made it susceptible to RIP, resulting in complete loss of cytosine methylation in M. graminicola.
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