ArticleThe Journal of biological chemistry2010
Contribution of the peroxisomal acox gene to the dynamic balance of daumone production in Caenorhabditis elegans.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 73 citations in OpenAlex.
- Comparative Metabolomics Identifies the Roles of Acyl-CoA Oxidases in the Biosynthesis of Ascarosides and a Complex Family of SecretedACS chemical biology · 2025Article
- An acyl-CoA thioesterase is essential for the biosynthesis of a key dauer pheromone in C. elegans.Cell chemical biology · 2024Article
- Peripheral peroxisomal β-oxidation engages neuronal serotonin signaling to drive stress-induced aversive memory in C. elegans.Cell reports · 2024Article
- Investigation of seasonal changes in lipid synthesis and metabolism-related genes in the oviduct of Chinese brown frog (<em>Rana dybowskii</em>).European journal of histochemistry : EJH · 2023Article
- Natural genetic variation in the pheromone production ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023Review
- Sexual morph specialisation in a trioecious nematode balances opposing selective forces.Scientific reports · 2022Article
- Chemical Signaling Regulates Axon Regeneration via the GPCR-Gqα Pathway inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Sea cucumber (Frontiers in nutrition · 2022Article
- Acyl-CoA oxidase ACOX-1 interacts with a peroxin PEX-5 to play roles in larval development of Haemonchus contortus.PLoS pathogens · 2021Article
- Functional Characterization ofFrontiers in plant science · 2021Article
- miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascaroside signaling.BMC biology · 2020Article
- A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones.Journal of the American Chemical Society · 2020Article
- A novel functional cross-interaction between opioid and pheromone signaling may be involved in stress avoidance in Caenorhabditis elegans.Scientific reports · 2020Article
- A Molecular Basis for Reciprocal Regulation between Pheromones and Hormones in Response to Dietary Cues inInternational journal of molecular sciences · 2020Article
- Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism.PLoS biology · 2019Article
- Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019Review
- Comparative Ascaroside Profiling of Caenorhabditis Exometabolomes Reveals Species-Specific (ω) and (ω - 2)-Hydroxylation Downstream of Peroxisomal β-Oxidation.The Journal of organic chemistry · 2018Article
- Biosynthetic tailoring of existing ascaroside pheromones alters their biological function ineLife · 2018Article
- Genetic deficiency in neuronal peroxisomal fatty acid β-oxidation causes the interruption of dauer development in Caenorhabditis elegans.Scientific reports · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dauer pheromones or daumones, which are signaling molecules that interrupt development and reproduction (dauer larvae) during unfavorable growth conditions, are essential for cellular homeostasis in Caenorhabditis elegans. According to earlier studies, dauer larva formation in strain N2 is enhanced by a temperature increase, suggesting the involvement of a temperature-dependent component in dauer pheromone biosynthesis or sensing. Several naturally occurring daumone analogs (e.g. daumones 1-3) have been identified, and these molecules are predicted to be synthesized in different physiological settings in this nematode. To elucidate the molecular regulatory system that may influence the dynamic balance of specific daumone production in response to sudden temperature changes, we characterized the peroxisomal acox gene encoding acyl-CoA oxidase, which is predicted to catalyze the first reaction during biosynthesis of the fatty acid component of daumones. Using acox-1(ok2257) mutants and a new, robust analytical method, we quantified the three most abundant daumones in worm bodies and showed that acox likely contributes to the dynamic production of various quantities of three different daumones in response to temperature increase, changes that are critical in C. elegans for coping with the natural environmental changes it faces.
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