ArticleThe Journal of biological chemistry2010
CCCTC-binding factor acts upstream of FOXA1 and demarcates the genomic response to estrogen.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics.Endocrine reviews · 2023Review
- Refining the genetic risk of breast cancer with rare haplotypes and pattern mining.Life science alliance · 2023Article
- Tales from topographic oceans: topologically associated domains and cancer.Endocrine-related cancer · 2019Review
- A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation.Nucleic acids research · 2019Article
- CTCF Expression is Essential for Somatic Cell Viability and Protection Against Cancer.International journal of molecular sciences · 2018Article
- Functional roles of CTCF in breast cancer.BMB reports · 2017Article
- Improved genome assembly of American alligator genome reveals conserved architecture of estrogen signaling.Genome research · 2017Article
- FOXK2 transcription factor suppresses ERα-positive breast cancer cell growth through down-regulating the stability of ERα via mechanism involving BRCA1/BARD1.Scientific reports · 2015Article
- Dynamic estrogen receptor interactomes control estrogen-responsive trefoil Factor (TFF) locus cell-specific activities.Molecular and cellular biology · 2014Article
- Nucleosome eviction and multiple co-factor binding predict estrogen-receptor-alpha-associated long-range interactions.Nucleic acids research · 2014Article
- Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells.Epigenetics · 2014Article
- Induction of the CLOCK gene by E2-ERα signaling promotes the proliferation of breast cancer cells.PloS one · 2014Article
- Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas.British journal of cancer · 2013Article
- FOXA1 mediates p16(INK4a) activation during cellular senescence.The EMBO journal · 2013Article
- FOXA1: a transcription factor with parallel functions in development and cancer.Bioscience reports · 2012Review
- A co-ordinated interaction between CTCF and ER in breast cancer cells.BMC genomics · 2011Article
- Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer.The EMBO journal · 2011Article
- FOXA1 is a key determinant of estrogen receptor function and endocrine response.Nature genetics · 2011Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription activation by estrogen receptor (ER) is rapid and dynamic. How the prompt and precise ER response is established and maintained is still not fully understood. Here, we report that two boundary elements surrounding the well defined ERalpha target TFF1 locus are occupied by the CCCTC-binding factor (CTCF). These elements are separated by 40 kb but cluster in the nuclear space depending on CTCF but independent of estrogen and transcription. In contrast, in estrogen non-responsive breast cancer cells, the spatial proximity of these two elements is lost and the entire locus instead displays a polycomb repressive complex 2-controlled heterochromatin characteristic. We showed that CTCF acts upstream of the "pioneer" factor FOXA1 in determining the genomic response to estrogen. We propose that the CTCF-bound boundary elements demarcate active versus inactive regions, building a framework of adjacent chromosome territory that predisposes ERalpha-regulated transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.