ArticleNeurotoxicology and teratology
Prenatal and postnatal cocaine exposure predict teen cocaine use.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- The Association Between Adverse Child Health, Psychological, Educational and Social Outcomes, and Nondependent Parental Substance: A Rapid Evidence Assessment.Trauma, violence & abuse · 2020Pooled it
- Pooled it
- Prenatal drug exposure, behavioral problems, and drug experimentation among African-American urban adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2014Trial
- Prenatal Substance Exposure.Annual review of developmental psychology · 2023Article
- Prenatal cocaine exposure and substance use disorder in emerging adulthood at age 21.Drug and alcohol dependence · 2023Article
- Co-occurrence of Psychopathology Problems in At-Risk Adolescents.Journal of psychopathology and behavioral assessment · 2022Article
- Article
- Effects of Fetal Substance Exposure on Offspring Substance Use.Pediatric clinics of North America · 2019Review
- Oscillatory Dynamics of Feedback Processing in Adolescents with Prenatal Cocaine Exposure.Developmental neuropsychology · 2019Article
- Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2019Article
- Prenatal drug exposure from infancy through emerging adulthood: Results from neuroimaging.Drug and alcohol dependence · 2019Review
- Prenatal cocaine exposure: Direct and indirect associations with 21-year-old offspring substance use and behavior problems.Drug and alcohol dependence · 2019Article
- Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse.Neurobiology of stress · 2018Review
- Pre- and postnatal tobacco and cannabis exposure and child behavior problems: Bidirectional associations, joint effects, and sex differences.Drug and alcohol dependence · 2018Article
- Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders.Birth defects research · 2017Review
- Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents.Drug and alcohol dependence · 2017Article
- Association of prenatal cocaine exposure, childhood maltreatment, and responses to stress in adolescence.Drug and alcohol dependence · 2017Article
- The association of prenatal cocaine exposure, externalizing behavior and adolescent substance use.Drug and alcohol dependence · 2017Article
- White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2017Article
- Gender-related Differences in Inhibitory Control and Sustained Attention among Adolescents with Prenatal Cocaine Exposure.The Yale journal of biology and medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Preclinical studies have identified alterations in cocaine and alcohol self-administration and behavioral responses to pharmacological challenges in adolescent offspring following prenatal exposure. To date, no published human studies have evaluated the relation between prenatal cocaine exposure and postnatal adolescent cocaine use. Human studies of prenatal cocaine-exposed children have also noted an increase in behaviors previously associated with substance use/abuse in teens and young adults, specifically childhood and teen externalizing behaviors, impulsivity, and attention problems. Despite these findings, human research has not addressed prior prenatal exposure as a potential predictor of teen drug use behavior. The purpose of this study was to evaluate the relations between prenatal cocaine exposure and teen cocaine use in a prospective longitudinal cohort (n=316) that permitted extensive control for child, parent and community risk factors. Logistic regression analyses and Structural Equation Modeling revealed that both prenatal exposure and postnatal parent/caregiver cocaine use were uniquely related to teen use of cocaine at age 14 years. Teen cocaine use was also directly predicted by teen community violence exposure and caregiver negativity, and was indirectly related to teen community drug exposure. These data provide further evidence of the importance of prenatal exposure, family and community factors in the intergenerational transmission of teen/young adult substance abuse/use.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.