ArticleThe Journal of infectious diseases2010
Proteomic analysis of cerebrospinal fluid in pneumococcal meningitis reveals potential biomarkers associated with survival.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cerebrospinal fluid quantitative proteomic reveals potential mechanisms and biomarker candidates of children with bacterial meningitis complicated by neurological complications.Clinical proteomics · 2025Article
- Synthetic peptide V11A reduces bacterial load and inflammation in pneumococcal meningitis.Frontiers in cellular and infection microbiology · 2025Article
- Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study.Encephalitis (Seoul, Korea) · 2023Article
- Article
- Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis.eLife · 2021Article
- CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults WithFrontiers in cellular and infection microbiology · 2020Article
- Targeting the complement system in bacterial meningitis.Brain : a journal of neurology · 2019Review
- Identifying genes associated with invasive disease in S. pneumoniae by applying a machine learning approach to whole genome sequence typing data.Scientific reports · 2019Article
- Proteomic and bioinformatic pipeline to screen the ligands of S. pneumoniae interacting with human brain microvascular endothelial cells.Scientific reports · 2018Article
- Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis.Scientific reports · 2017Article
- Cerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children.Wellcome open research · 2017Article
- Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics.Frontiers in pediatrics · 2017Review
- Article
- Genomic pneumococcal load and CSF cytokines are not related to outcome in Malawian adults with meningitis.The Journal of infection · 2014Article
- Cerebrospinal fluid proteome of patients with acute Lyme disease.Journal of proteome research · 2012Article
- Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundPatients with pneumococcal meningitis often die or have severe neurological damage despite optimal antibiotic therapy. New or improved therapy is required. The delivery of new interventions will require an improved understanding of the disease pathogenesis. Our objective was to learn more about the pathophysiology of severe meningitis through the interpretation of differences in the proteomic profile of cerebrospinal fluid (CSF) from patients with meningitis.
methodsTwo-dimensional polyacrylamide gel electrophoresis of CSF from normal subjects (controls, n = 10) and patients with pneumococcal meningitis (n = 20) was analyzed. Spot differences were compared and identified between controls, nonsurvivors (n = 9), and survivors (n = 11).
resultsProtein concentration in CSF of patients with meningitis was 4-fold higher than in CSF of control subjects (7.0 mg/mL vs 0.23 mg/mL; P < .01). A mean of 2466 discrete protein spots was present in CSF of patients with meningitis. Thirty-four protein spots were differentially expressed in CSF of nonsurvivors, compared with survivors. None of these protein spots were observed in CSF of control subjects.
conclusionsProteomic screening of CSF yields potential biomarkers capable of differentiating control subjects from nonsurvivors and survivors of meningitis. Proteins involved in the inflammatory process and central metabolism were represented in the differentially expressed protein repertoire.
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