ArticleInflammopharmacology2011
Inhibition of pro-inflammatory mediators: role of Bacopa monniera (L.) Wettst.
Article in Inflammopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Comparative Metabolomics and Network Pharmacology Analysis Reveal Shared Neuroprotective Mechanisms of Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb.Molecular neurobiology · 2024Article
- Bacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish.Metabolic brain disease · 2022Article
- Dereplication Based Strategy for Rapid Identification and Isolation of a Novel Anti-inflammatory Flavonoid by LCMS/MS fromACS omega · 2021Article
- A randomized phase II remote study to assess Bacopa for Gulf War Illness associated cognitive dysfunction: Design and methods of a national study.Life sciences · 2021Article
- Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies.Chinese medicine · 2021Review
- Chemical composition of Polish propolis and its antiproliferative effect in combination with Bacopa monnieri on glioblastoma cell lines.Scientific reports · 2020Article
- Bacopa monnieri prevents colchicine-induced dementia by anti-inflammatory action.Metabolic brain disease · 2019Article
- An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain.Journal of experimental neuroscience · 2018Review
- A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats.BMC complementary and alternative medicine · 2017Article
- The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain.Journal of ethnopharmacology · 2017Article
- Article
- The Molecular Links of Re-Emerging Therapy: A Review of Evidence of Brahmi (Bacopa monniera).Frontiers in pharmacology · 2016Review
- Bacopa monniera ameliorates cognitive impairment and neurodegeneration induced by intracerebroventricular-streptozotocin in rat: behavioral, biochemical, immunohistochemical and histopathological evidences.Metabolic brain disease · 2015Article
- Bacoside A: Role in Cigarette Smoking Induced Changes in Brain.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Standardized Extract of Bacopa monniera Attenuates Okadaic Acid Induced Memory Dysfunction in Rats: Effect on Nrf2 Pathway.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Amelioration of age associated neuroinflammation on long term bacosides treatment.Neurochemical research · 2012Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Bacopa monniera (L.) Wettst is a renowned plant in the Ayurvedic system of medicine. The present study seeks to identify the anti-inflammatory activity of two fractions from the methanolic extract of Bacopa, viz. the triterpenoid and bacoside-enriched fractions. The ability of these two fractions to inhibit the production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 was tested using lipopolysaccharide (LPS)-activated peripheral blood mononuclear cells and peritoneal exudate cells in vitro. We found that triterpenoid and bacoside-enriched fractions significantly inhibited LPS-activated TNF-α, IL-6 and nitrite production in mononuclear cells. Significant antioxidant activity was exhibited by the bacoside enriched fraction compared to the triterpenoid fraction. Carrageenan-induced hind paw oedema assay revealed that triterpenoid and bacoside-enriched fractions exerted anti-oedematogenic effect, while in the arthritis model only the triterpenoid fraction exerted an anti-arthritic potential. The present study provides an insight into the ability of Bacopa monniera to inhibit inflammation through modulation of pro-inflammatory mediator release.
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