ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2010
Rebamipide inhibits tumor necrosis factor-α-induced interleukin-8 expression by suppressing the NF-κB signal pathway in human umbilical vein endothelial cells.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Investigation of the preventive action of rebamipide versus cadmium nephrotoxicity effect in rats.Irish journal of medical science · 2026Article
- [Effect of rebamipide on the acute gouty arthritis in rats induced by monosodium urate crystals].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis.Current rheumatology reviews · 2018Review
- Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1β Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells.Inflammation · 2016Article
- Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts.BioMed research international · 2016Article
- Association between Interleukin-8-251A/T polymorphism and gastric cancer susceptibility: a meta-analysis based on 5286 cases and 8000 controls.International journal of clinical and experimental medicine · 2015Article
- The Efficacy of 2% Topical Rebamipide on Conjunctival Squamous Metaplasia and Goblet Cell Density in Dry Eye Disease.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and TherapeuticsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was designed to identify the inhibitory effect of rebamipide on tumor necrosis factor-α (TNF-α)-induced interleukin-8 (IL-8) production and nuclear factor-κB (NF-κB) activation in human umbilical vein endothelial cells (HUVECs).
methodsAfter stimulation with TNF-α, HUVECs were treated with rebamipide in a dose-dependent manner. The viability of HUVECs was assessed using methylthiazol tetrazolium assay after 24 h incubation with rebamipide. TNF-α-induced IL-8 expression was determined by enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (RT-PCR). TNF-α-induced IκB-α phosphorylation and translocation of NF-κB p65 subunit into nucleus in endothelial cells were assessed using immunoblot analysis.
resultsWe found that rebamipide decreased the expression of IL-8 in the dose-dependent manner under the treatment with TNF-α 10 ng/ml. TNF-α-induced degradation of IκB-α at 15 min was maximally observed and rebamipide (2 mM) inhibited TNF-α-induced phosphorylation of IκB-α in the cytoplasm of endothelial cells by western blot analysis. Rebamipide also suppressed TNF-α-stimulated NF-κB p65 nuclear translocation.
conclusionRebamipide suppresses TNF-α-induced IL-8 production through (1) inhibition of IκB-α phosphorylation in the cytoplasm and (2) blockage of NF-κB p65 protein transport into the nucleus. We suggest that the anti-inflammatory effect of rebamipide is related to the down-regulation of IL-8 expression that is important in endothelial inflammation.
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