ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2010
Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Pooled it
- Review
- Article
- Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration.Pharmaceutics · 2022Review
- [Establishment of artificial joint aseptic loosening mouse model by cobalt-chromium particles stimulation].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Metal Nanoparticles Released from Dental Implant Surfaces: Potential Contribution to Chronic Inflammation and Peri-Implant Bone Loss.Materials (Basel, Switzerland) · 2019Article
- Endoplasmic reticulum stress-mediated inflammatory signaling pathways within the osteolytic periosteum and interface membrane in particle-induced osteolysis.Cell and tissue research · 2016Article
- A histomorphometric study of the effect of doxycycline and erythromycin on bone formation in dental alveolar socket of rat.Advanced biomedical research · 2015Article
- Are biologic treatments a potential approach to wear- and corrosion-related problems?Clinical orthopaedics and related research · 2014Review
- Mitigative effect of erythromycin on PMMA challenged preosteoblastic MC3T3-E1 cells.TheScientificWorldJournal · 2014Article
- Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages.Free radical biology & medicine · 2012Article
- Emerging ideas: can erythromycin reduce the risk of aseptic loosening?Clinical orthopaedics and related research · 2011Article
- Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application.International journal of nanomedicine · 2011Article
- Evaluation of the effects of two different bone resorption inhibitors on osteoclast numbers and activity: An animal study.Dental research journalArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe have reported that oral erythromycin (EM) inhibits periprosthetic tissue inflammation in a group of patients with aseptic loosening. The purpose of this study was to assess the efficacy of local, periprosthetic EM delivery in a rat model.
methodsUncoated Ti pins were press-fit into the right tibia of fourteen Sprague-Dawley rats following an intramedullar injection of UHMWPE (ultra high molecular weight polyethylene) particles. Revision surgeries were performed 2 months after the primary surgery. EM was applied to the Peri-Apatite™ (PA) layer of the titanium (Ti) pins. The previously implanted Ti pins were withdrawn and replaced with Ti pins coated either with (n = 7) or without (n = 7) EM. The rats were killed 1 month after "revision surgery". The EM efficacy was evaluated by (MicroCT) μCT and histology.
resultsμCT analysis showed that bone volume percentage (BV/TV) was significantly higher in the EM-treated group compared to the untreated group (p < 0.05). Histological analysis showed that EM treatment inhibits UHMWPE particle-induced periprosthetic tissue inflammation compared to the untreated group.
conclusionThis study demonstrated that periprosthetic EM delivery reduced periprosthetic inflammation and improved the quality of surrounding bone.
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