ArticleAge (Dordrecht, Netherlands)2011
Age-related cataract in dogs: a biomarker for life span and its relation to body size.
Article in Age (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Nutrition Research in Aging Dogs and Cats: What We Know and What We Need to Do.Animals : an open access journal from MDPI · 2026Review
- Antioxidant Strategies for Age-Related Oxidative Damage in Dogs.Veterinary sciences · 2025Review
- A biological age based on common clinical markers predicts health trajectory and mortality risk in dogs.GeroScience · 2025Article
- Longevity of companion dog breeds: those at risk from early death.Scientific reports · 2024Article
- Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans.PLoS genetics · 2023Article
- Comparative proteomics in captive giant pandas to identify proteins involved in age-related cataract formation.Scientific reports · 2023Article
- Age-associated changes in electroretinography measures in companion dogs.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- The Relationship between Signs of Medical Conditions and Cognitive Decline in Senior Dogs.Animals : an open access journal from MDPI · 2023Article
- Effect of oral antioxidants on the progression of canine senile cataracts: a retrospective study.Journal of veterinary science · 2022Article
- RNA-Seq analysis in giant pandas reveals the differential expression of multiple genes involved in cataract formation.BMC genomic data · 2021Article
- Use of the Milan Pet Quality of Life Instrument (MPQL) to Measure Pets' Quality of Life during COVID-19.Animals : an open access journal from MDPI · 2021Article
- The ophthalmic health and refractive state of working dogs in South Brazil.Open veterinary journal · 2020Article
- Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States.Canine medicine and genetics · 2020Article
- Article
- Longevity: Lesson from Model Organisms.Genes · 2019Review
- Article
- Owner reported sensory impairments affect behavioural signs associated with cognitive decline in dogs.Behavioural processes · 2018Article
- When Veterinarians Support Canine Therapy: Bidirectional Benefits for Clinics and Therapy Programs.Veterinary sciences · 2018Article
- Cellular metabolism and oxidative stress as a possible determinant for longevity in small breed and large breed dogs.PloS one · 2018Article
- The dog aging project: translational geroscience in companion animals.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Clinical data from 72 dog breeds of varying size and life expectancy were grouped according to breed body mass and tested for prevalence at ages 4 to 5, ages 7 to 10, and lifetime incidence of non-hereditary, age-related cataract (ARC). The incidence of ARC was found to be directly related to the relative life expectancies in the breed groups: The smallest dog breeds had a lower ARC prevalence between ages 4 and 5 than mid-size breeds and these, in turn, a lower prevalence than the giant breeds. A similar sequence was evident for ages 7 to 10 and for overall lifetime incidence of ARC. These differences became more significant when comparing small and giant breeds only. We could also confirm the inverse relationship between body size and life expectancy in these same sets of dog breeds. Our results show that body size, life expectancy, and ARC incidence are interrelated in dogs. Given that ARC has been shown to be at least partially caused by oxidative damage to lens epithelial cells and the internal lens, we suggest that it can be considered not only as a general biomarker for life expectancy in the canine and possibly other species, but also for the systemic damages produced by reactive oxygen species. This suggests new approaches to examine the gene expression pathways affecting the above-noted linkages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.