Evidence map›Paper›PMID 20607302›Full record

ArticlePediatric nephrology (Berlin, Germany)2010

Alterations in appetite-regulating hormones influence protein-energy wasting in pediatric patients with chronic kidney disease.

Anja K Büscher, Rainer Büscher, Berthold P Hauffa, Peter F Hoyer

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03171116 (Unacylated Ghrelin and Obestatin as Promising Biomarkers of Protein Energy Wasting in Children With Chronic Kidney Disease), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03171116 completednot on this mapstarted 2013, after this paper: background citation

Unacylated Ghrelin and Obestatin as Promising Biomarkers of Protein Energy Wasting in Children With Chronic Kidney Disease: a Cross-sectional Case-control Study

TypeobservationalSponsorAzienda Ospedaliero Universitaria Maggiore della CaritaRan2013 to 2015Enrolled154ConditionsChronic Kidney DiseasesArmsnone intervention
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Podocin oligomers regulate the ordering of nephrin chains, providing the molecular basis ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Malnutrition management in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2025
    Review
  5. Article
  6. Review
  7. Adipose tissue metabolic changes in chronic kidney disease.Immunometabolism (Cobham, Surrey) · 2023
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Pathophysiology of Non Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2016
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Ghrelin and cachexia in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anja K BüscherDepartment of Pediatrics II, Pediatric Nephrology, Endocrinology, Gastroenterology and Transplant Medicine, Children's Hospital, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany. anja.buescher@uk-essen.de
Rainer Büscher
Berthold P Hauffa
Peter F Hoyer
University of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-energy wasting is a common problem in pediatric patients with chronic kidney disease (CKD). Disturbances in appetite-regulating hormones have been suggested as causative factors. Acyl ghrelin is a potent orexigenic hormone, whereas desacyl ghrelin and obestatin have the opposite effect. The regulation of acyl ghrelin and its anorexigenic opponents and its role in the development of CKD-associated protein-energy wasting is poorly understood. We measured total and acylated ghrelin, obestatin, leptin, and adiponectin in children with CKD (n=29), children undergoing hemodialysis (HD) or peritoneal dialysis (PD; n=29), renal transplant recipients (RTx; n=91), and healthy controls (n=27), and analyzed the data in relation to body mass index (BMI) and height. Patients with renal insufficiency showed lower BMI standard deviation score (SDS) values and height SDS compared with controls and RTx patients. Total ghrelin was elevated in CKD and dialyzed patients compared with controls or transplant recipients (P<0.001). Acyl ghrelin did not differ between groups, and the acyl ghrelin/total ghrelin ratio was reduced in uremic patients (P<0.05). Obestatin plasma levels were increased in patients with renal insufficiency compared with controls and RTx patients (P<0.01). Uremia leads to an accumulation of the anorexigenic hormones desacyl ghrelin and obestatin. Orexigens like acyl ghrelin are not elevated. A disturbed balance between anorexigenic and orexigenic hormones may influence development of CKD-associated protein-energy wasting in pediatric patients.

Indexed as

AdiponectinBody HeightBody Mass IndexChildFemaleGhrelinHumansLeptinMaleRenal Insufficiency, ChronicWasting SyndromeAdiponectinGhrelinLeptin

Identifiers

PMID20607302
OpenAlexW2001268711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.