ArticleEuropean journal of clinical pharmacology2010
Haemodynamics of intravenous paracetamol in neonates.
Article in European journal of clinical pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02280239 (Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Intravenous acetaminophen for postoperative pain control after open abdominal and thoracic surgery in pediatric patients: a systematic review and meta-analysis.Pediatric surgery international · 2022Pooled it
- Paracetamol (acetaminophen) use in infants and children was never shown to be safe for neurodevelopment: a systematic review with citation tracking.European journal of pediatrics · 2022Pooled it
- [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].Schmerz (Berlin, Germany) · 2014Guideline
- Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach.Paediatric drugs · 2024Trial
- Paracetamol Concentrations and Time-Course of Ductus Arteriosus Diameter in Extremely Preterm Neonates: A Population Pharmacokinetic-Pharmacodynamic Analysis.Clinical pharmacokinetics · 2025Article
- Comments on the efficacy of paracetamol in the management of hemodynamically significant patent ductus arteriosus in preterm newborns.Indian journal of pharmacology · 2024Article
- Incidence of Hemodynamic Changes Following Intravenous Acetaminophen Administration in Critically Ill Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Review
- Acetaminophen increases pulmonary and systemic vasomotor tone in the newborn rat.Pediatric research · 2020Article
- Hemodynamic effects of intravenous paracetamol in critically ill children with septic shock on inotropic support.Journal of intensive care · 2020Article
- A Critical Review on the Relevance of Paracetamol for Procedural Pain Management in Neonates.Frontiers in pediatrics · 2020Review
- The Hemodynamic Effect of Intravenous Paracetamol in Children: A Retrospective Chart Review.Paediatric drugs · 2019Review
- Clinical pharmacology of analgosedatives in neonates: ways to improve their safe and effective use.The Journal of pharmacy and pharmacology · 2017Review
- Neonatal pain management: still in search for the Holy Grail.International journal of clinical pharmacology and therapeutics · 2016Review
- Clinical pharmacology of paracetamol in neonates: a review.Current therapeutic research, clinical and experimental · 2015Review
- Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.European journal of pediatrics · 2015Observational
- Breastfeeding and migraine drugs.European journal of clinical pharmacology · 2014Review
- Neonatal pain.Paediatric anaesthesia · 2014Review
- Pharmacological treatment of neonatal pain: in search of a new equipoise.Seminars in fetal & neonatal medicine · 2013Review
- [Paracetamol for perioperative analgesia. Old substance - new insights].Der Anaesthesist · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionReports on the haemodynamics of intravenous (iv) paracetamol in adult intensive care were recently published. We therefore wanted to explore the haemodynamics of iv paracetamol in neonates.
methodsRetrospective, pooled analysis of heart rate (bpm) and blood pressure (mean, systolic, diastolic) observations collected during iv paracetamol pharmacokinetic studies in neonates. Heart rate and blood pressure were recorded just before and 30, 60, 120, 180, 240, 300 and 360 min after iv paracetamol (paired, ANOVA). Clinical characteristics in hypotensive (mean mmHg < gestational age, weeks) cases were compared with controls (Mann-Whitney U test).
resultsBased on observations in 72 neonates, heart rate decreased from 145 (SD 20) to 138 (21), 141 (20), 137 (20), 137 (22), 140 (20), 139 (20) and 140 (21) bpm (paired p < 0.05, ANOVA p = 0.36). There were no changes in systolic and diastolic pressure, but mean arterial pressure decreased from 46 (7) to 43 (8) mmHg at 60 min (paired p < 0.05, ANOVA p = 0.75). Eight neonates developed hypotension. These patients had lower pre-administration arterial pressure (38 vs 47 mmHg, p < 0.05).
conclusionsIn a setting of open label administration to alleviate (procedural) pain, haemodynamic effects of iv paracetamol in neonates remained modest. We suggest considering impaired haemodynamics to be a relative contra-indication for iv paracetamol in neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.