Evidence map›Paper›PMID 20607196›Full record

ArticleChemical communications (Cambridge, England)2011

An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products.

Nicholas A McGrath, Joshua R Binner, Georgios Markopoulos, Matthew Brichacek, Jon T Njardarson

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas A McGrathDepartment of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY, USA.
Joshua R Binner
Georgios Markopoulos
Matthew Brichacek
Jon T Njardarson

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
Total Synthesis of Bicyclic Bioactive DiterpenoidsR01GM086584 · NIGMS · UNIVERSITY OF ARIZONA · PI NJARDARSON, JON T · 2009 to 2013
$1.7M
NIGMS NIH HHS R01 GM086584NIGMS NIH HHS T32 GM008500NIGMS NIH HHS T32GM008500
6 · The paper itself

Abstract

Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate.

Indexed as

Biological ProductsBridged Bicyclo CompoundsComputer SimulationCyclizationFree RadicalsMolecular StructureOxidation-ReductionPhloroglucinolStereoisomerismTerpenesBiological ProductsBridged Bicyclo CompoundsFree Radicalsguttiferone GPhloroglucinolTerpenes

Identifiers

PMID20607196
PMCPMC3107033

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.