ArticleIndian journal of pharmacology2010
Adverse drug reaction profile of cisplatin-based chemotherapy regimen in a tertiary care hospital in India: An evaluative study.
Article in Indian journal of pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Science behind cisplatin-induced nephrotoxicity in humans: a clinical study.Asian Pacific journal of tropical biomedicine · 2012Trial
- Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells.PloS one · 2025Article
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- Adverse drug events and contributing factors among pediatric cancer patients at Jimma University medical center, Southwest Ethiopia.BMC pediatrics · 2023Observational
- Quality of life and wellbeing among breast cancer patients in Lahore, Pakistan.Frontiers in oncology · 2023Article
- Potent Chlorambucil-Platinum(IV) Prodrugs.International journal of molecular sciences · 2022Article
- Severity in schizophrenia patients receiving atypical antipsychotic medications.Bioinformation · 2022Article
- Modulatory role of garlic (F1000Research · 2022Article
- Frequency, nature, severity and preventability of adverse drug reactions arising from cancer chemotherapy in a teaching hospital.Journal of family medicine and primary care · 2020Article
- Intercycle Unplanned Hospital Admissions Due to Cisplatin-based Chemotherapy Regimen-induced Adverse Reactions: A Retrospective Analysis.Current drug safety · 2019Article
- Adverse drug reactions and kinetics of cisplatin excretion in urine of patients undergoing cisplatin chemotherapy and radiotherapy for head and neck cancer: a prospective study.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2017Article
- Adverse drug reactions due to cancer chemotherapy in a tertiary care teaching hospital.Therapeutic advances in drug safety · 2017Article
- A retrospective evaluation of activity of gemcitabine/platinum regimens in the treatment of recurrent ovarian cancer.Gynecologic oncology research and practice · 2017Article
- Assessment of drug therapy problems among patients with cervical cancer at Kenyatta National Hospital, Kenya.Gynecologic oncology research and practice · 2017Article
- Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells.Molecular medicine reports · 2015Article
- A prospective study on Adverse Drug Reactions of antibiotics in a tertiary care hospital.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2014Article
- Pharmacovigilance of Cutaneous Adverse Drug Reactions among Patients Attending Dermatology Department at a Tertiary Care Hospital.Indian dermatology online journalArticle
- A retrospective analysis of reporting of adverse drug reactions to oncology drugs: An experience from a national center of clinical excellence.Indian journal of pharmacologyArticle
- Pattern and impact of drugs targeted toward toxicity amelioration in patients receiving cancer chemotherapy.Perspectives in clinical researchArticle
- Pattern of Adverse Drug Reactions to Anticancer Drugs: A Quantitative and Qualitative Analysis.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric OncologyArticle
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6 authors.
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Abstract
aimsThis prospective study was designed to monitor and analyze the pattern of occurrence of adverse drug reactions (ADRs) to cisplatin-based chemotherapy regimen in the cancer ward of a tertiary care hospital. MATERIALS AND
methodsCancer patients who received cisplatin-based cancer chemotherapy were monitored for adverse reactions. The collected reports were analyzed for demographic and drug details, causality, preventability and severity of adverse effects. Causality was assessed by the World Health Organization (WHO) causality assessment scale and Naranjo's Algorithm. Preventability and severity of ADRs were assessed by modified Schumock and Thornton scale, modified Hartwig and Siegel scale respectively.
resultsAmong 51 patients, 48 developed ADRs to cisplatin chemotherapy. The reactions observed were nausea, alopecia, anorexia, vomiting, taste alteration, diarrhea, constipation, tinnitus, and hypocalcaemia. The WHO causality assessment scale indicated 69% "possible" and 31% "probable" but no "certain" reactions. Naranjo's Algorithm showed 62% "probable" and 38% "possible" reactions. Most of the reactions belonged to the category of "not preventable". Reactions like nausea and vomiting belonged to the category of "definitely preventable". Modified Hartwig and Siegel scale of severity assessment showed that most of the reactions were of "mild level 1" severity except for vomiting, diarrhea and hypocalcaemia, which were of "moderate level 3" severity.
conclusionCisplatin-based chemotherapy has a high potential to cause adverse effects. Most of the reactions were of milder nature but not preventable. The common adverse effects such as nausea and vomiting were preventable, but reactions like hypersensitivity reactions and anaphylaxis were not predictable.
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