ArticleIndian journal of pharmacology2010
Effect of pantoprazole and its interactions with vecuronium on the neuromuscular junction.
Article in Indian journal of pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Signals of Muscle Relaxant Drug Interactions Associated with Unintentional Traumatic Injury: A Population-Based Screening Study.CNS drugs · 2022Article
- Effect of Zidovudine and its interaction with rocuronium on neuromuscular transmission.Indian journal of pharmaceutical sciences · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the effect of pantoprazole on neuromuscular transmission and its interactions with vecuronium at the neuromuscular junction (NMJ). MATERIALS AND
methodsEffect of pantoprazole on neuromuscular transmission (2 muM - 16 mM) and reversal of neuromuscular blockade by pantoprazole and vecuronium with neostigmine (3.3 muM), 3,4-diaminopyridine (0.25 mM), KCl (6 mM), and CaCl(2) (10 mM) were studied by the indirect and direct stimulated preparation of rat phrenic nerve hemidiaphragm. Cumulative reponse curves (CRC) of vecuronium (1 muM to 32 muM) were studied in the absence and presence of 32 muM, 64 muM, and 128 muM pantoprazole. Time for head drop by vecuronium infusion was recorded in the absence and presence of acute and chronic administration of pantoprazole (1.9 mg/kg) in rabbits.
resultsPantoprazole potentiated the basal contractile twitch responses at a lower concentration followed by neuromuscular blockade at a higher concentration. The neuromuscular blockade was not reversed by neostigmine (3.3 muM), 3,4-diaminopyridine (0.25 mM), KCl (6 mM), and CaCl(2) (10 mM). Pantoprazole potentiated the vecuronium-induced neuromuscular blockade. It decreased the total time for complete blockade in rat phrenic nerve hemidiaphragm preparation (P < 0.05) and decreased the time for the head drop in rabbits with vecuronium infusion (P < 0.0001).
conclusionPantoprazole has a direct neuromuscular blocking action. It has the potential to interact with vecuronium.
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