ReviewPediatric research2010
Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome.
Review in Pediatric research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06915285 (Analyzing the Performance of Automated Software in the Identification of Malarial Retinopathy in Digital Retinal Images of Cerebral Malaria Patients), which is not on this map. Cited by 280 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analyzing the Performance of Automated Software in the Identification of Malarial Retinopathy in Digital Retinal Images of Cerebral Malaria Patients
Who cites it
280 citing papers in PubMed, 3 syntheses or guidelines pooled it, 553 citations in OpenAlex.
- Prevalence and risk factors of gross neurologic deficits in children after severe malaria: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Utilization of insecticide-treated nets for malaria prevention among children in Africa: a systematic review and meta-analysis.Malaria journal · 2025Pooled it
- Association of severe malaria with cognitive and behavioural outcomes in low- and middle-income countries: a meta-analysis and systematic review.Malaria journal · 2023Pooled it
- Hemophagocytic Lymphohistiocytosis Criteria Overlap with Severe Malaria Features in Children.Open forum infectious diseases · 2026Article
- Neuroimaging access in Chad: Infrastructure barriers and opportunities for accessible magnetic resonance imaging.medRxiv : the preprint server for health sciences · 2026Article
- Global Proteomic Profiling of Cerebral Malaria-Infected Erythrocytes Reveals a Specific PfEMP1 Expression Pattern.Molecular & cellular proteomics : MCP · 2026Article
- Synthesis, antimalarial activity, and cytotoxicity of ethyl 4-oxocyclohexane-1-carboxylate-based 1,2,4,5-tetraoxanes: anRSC advances · 2026Article
- Cerebral Malaria and Severe Malarial Anemia, but not Other Forms of Severe Malaria, Are Associated With Long-Term Cognitive Impairment.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Observational
- Pathogens of the Human Central Nervous System-the Major Protozoan Parasites and Helminths.Molecular neurobiology · 2026Review
- Plasmodium-induced disruption of brain endothelial barrier integrity in vitro and in mice is prevented by inhibitors of farnesyltransferase.Malaria journal · 2026Article
- Cerebral malaria in resource-limited African regions: Diagnostic and therapeutic challenges.Infectious medicine · 2026Review
- Article
- Malaria and bacteremia in febrile children presenting at a teaching hospital in Kumasi, Ghana.BMC infectious diseases · 2026Article
- From parasite-induced immune activation to neuroinflammation and behavioral dysfunction: convergent mechanisms across protozoa and helminths: a review.Journal of neuroinflammation · 2026Review
- Article
- A Pilot Feasibility Study of a Home Tablet-Based Neurorehabilitation Program and Serial Brain Vital Sign Monitoring for Survivors of Pediatric Cerebral Malaria.The American journal of tropical medicine and hygiene · 2026Article
- Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria.Blood advances · 2026Article
- Altered natural killer cell function in children with severe malaria.ImmunoHorizons · 2026Article
- Understanding malaria vector dynamics and transmission in the Pouth-Kelle community, Nyong et Kelle division, Centre Region, Cameroon.Frontiers in public health · 2026Article
220 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 7 countries.
Funding
Abstract
Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cerebral malaria a leading cause of childhood neurodisability in the region. The pathogenesis of neurocognitive sequelae is poorly understood: coma develops through multiple mechanisms and there may be several mechanisms of brain injury. It is unclear how an intravascular parasite causes such brain injury. Understanding these mechanisms is important to develop appropriate neuroprotective interventions. This article examines possible mechanisms of brain injury in cerebral malaria, relating this to the pathogenesis of the disease, and explores prospects for improved neurocognitive outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.