ArticleDementia and geriatric cognitive disorders2010
Occupational exposure to solvents and cognitive performance in the GAZEL cohort: preliminary results.
Article in Dementia and geriatric cognitive disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Multidimensional workplace stressors differentially impact cognitive trajectories.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Novel Strategy to Assess the Neurotoxicity of Organic Solvents Such as Glycol Ethers: Protocol for Combining In Vitro and In Silico Methods With Human-Controlled Exposure Experiments.JMIR research protocols · 2024Article
- Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene.Biomolecules & therapeutics · 2021Article
- Changes in cognitive function and related brain regions in chronic benzene poisoning: a case report.Annals of translational medicine · 2021Article
- Association between occupational solvent exposure and cognitive performance in the French CONSTANCES study.Occupational and environmental medicine · 2020Article
- Deepwater Horizon oil spill exposures and neurobehavioral function in GuLF study participants.Environmental research · 2019Article
- Neurobehavioral Effects of Organic Solvents Exposure Among Wood Furniture Makers in Ile-Ife, Osun State, Southwestern Nigeria.Journal of health & pollution · 2019Article
- Workplace Exposures and Cognitive Function During Adulthood: Evidence From National Survey of Midlife Development and the O*NET.Journal of occupational and environmental medicine · 2016Article
- Time may not fully attenuate solvent-associated cognitive deficits in highly exposed workers.Neurology · 2014Article
- Occupational exposure to mineral turpentine and heavy fuels: a possible risk factor for Alzheimer's disease.Dementia and geriatric cognitive disorders extra · 2014Article
- Physical occupational exposures during working life and quality of life after labour market exit: results from the GAZEL study.Aging & mental health · 2013Article
- Occupational solvent exposure and cognition: does the association vary by level of education?Neurology · 2012Article
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6 authors.
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Abstract
backgroundThe impact of occupational exposure to solvents on cognitive ageing remains unclear. We examined whether long-term occupational exposure is associated with poor cognitive performance in late midlife.
methodsParticipants in the GAZEL cohort, set up in 1989, are employees of the French national electricity and gas company. Data on the working environment were used to create measures of cumulative exposures to solvents using a job-exposure matrix. In 2002-2004, cognitive performance was assessed using the Digit Symbol Substitution Test (DSST) and the Mini Mental State Examination in 5,242 participants (aged 55-65 years).
resultsIn cross-sectional analysis using multiple logistic regression, there was a greater risk of poor cognitive performance (DSST score <25th percentile) among those with high exposure to benzene (OR = 1.58; 95% CI 1.31-1.90) and the grouped categories of chlorinated (OR = 1.39; 95% CI 1.3-2.3), aromatic (OR = 1.76; 95% CI 1.08-2.87), and petroleum solvents (OR = 1.50; 95% CI 1.23-1.81).
conclusionsThese results suggest that occupational exposures to solvents may be associated later in life with cognitive impairment, even after taking into account the effects of education, employment grade, and numerous health factors.
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