ArticleCells, tissues, organs2010
The expression of sphingosine kinase-1 in head and neck carcinoma.
Article in Cells, tissues, organs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Increased Sphingosine Kinase 1 Expression Is Associated with Poor Prognosis in Human Solid Tumors: A Meta-Analysis.Disease markers · 2022Pooled it
- Tissue-specific fibroblast lipid cues impose the rate of epithelial cancer invasion.Nature metabolism · 2026Article
- Lipid metabolism reprogramming in head and neck cancer.Frontiers in oncology · 2023Review
- LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR‑378a‑5p to enhance SPHK1 expression.International journal of oncology · 2021Article
- Profile of sphingolipid-related genes and its association with prognosis highlights sphingolipid metabolism in oral cancer.Cancer biomarkers : section A of Disease markers · 2021Article
- Review
- Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.Biomarker research · 2018Article
- Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.Oncology letters · 2017Article
- Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.American journal of translational research · 2017Article
- Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.Scientific reports · 2016Article
- The emerging role of FTY720 (Fingolimod) in cancer treatment.Oncotarget · 2016Review
- Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma.OncoTargets and therapy · 2016Review
- Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.Oncotarget · 2015Article
- A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Sphingosine kinase 1 as an anticancer therapeutic target.Drug design, development and therapy · 2015Review
- High expression of SPHK1 in sacral chordoma and association with patients' poor prognosis.Medical oncology (Northwood, London, England) · 2014Article
- Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.Oncotarget · 2014Article
- Vitamin D receptor expression is associated with improved overall survival in human glioblastoma multiforme.Journal of neuro-oncology · 2014Article
- Heme oxygenase-1 expression in human gliomas and its correlation with poor prognosis in patients with astrocytoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Increased SPHK1 expression is associated with poor prognosis in bladder cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Sphingosine kinase-1 (SPHK1) modulates the proliferation, apoptosis and differentiation of keratinocytes through the regulation of ceramide and sphingosine-1-phosphate levels. However, studies on the expression of SPHK1 in human head and neck squamous cell carcinoma (HNSCC) specimens are lacking. Therefore, the aim of the present work was to evaluate SPHK1 expression in human primary HNSCCs and to correlate the results with clinical and anatomopathological parameters. We investigated the expression of this protein by immunohistochemistry performed in tissue microarrays of HNSCC and in an independent cohort of 37 paraffin-embedded specimens. SPHK1 expression was further validated by real-time PCR performed on laser capture-microdissected tissue samples. The positive rate of SPHK1 protein in the cancerous tissues was significantly higher (74%) than that in the nontumor oral tissues (23%), and malignant tissues showed stronger immunoreactivity for SPHK1 than normal matching samples. These results were confirmed by real-time PCR quantification of SPHK1 mRNA. Interestingly, the positive expression of SPHK1 was associated with shorter patient survival time (Kaplan-Meier survival curves) and with the loss of p21 expression. Taken together, these results demonstrate that SPHK1 is upregulated in HNSCC and provide clues of the role SPHK1 might play in tumor progression.
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