ArticleThe Journal of biological chemistry2010
Functional diversity in fungal fatty acid synthesis: the first acetylenase from the Pacific golden chanterelle, Cantharellus formosus.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Divergent fatty acid desaturase 2 is essential for falcarindiol biosynthesis in carrot.Plant communications · 2025Article
- The alkynyl-containing compounds from mushrooms and their biological activities.Natural products and bioprospecting · 2023Review
- Thiotemplated Biosynthesis of Bacterial Polyyne Fatty Acids by a Designated Desaturase Triad.Chembiochem : a European journal of chemical biology · 2022Article
- Identification of Substances Produced byJournal of fungi (Basel, Switzerland) · 2021Article
- Biosynthesis of alkyne-containing natural products.RSC chemical biology · 2021Review
- Secondary metabolites from hypocrealean entomopathogenic fungi: novel bioactive compounds.Natural product reports · 2020Review
- Identification of Genes Encoding Enzymes Catalyzing the Early Steps of Carrot Polyacetylene Biosynthesis.Plant physiology · 2018Article
- Biocatalytic portfolio of Basidiomycota.Current opinion in chemical biology · 2016Review
- Bacterial Genome Mining of Enzymatic Tools for Alkyne Biosynthesis.ACS chemical biology · 2015Article
- De novo biosynthesis of terminal alkyne-labeled natural products.Nature chemical biology · 2015Article
- Biosynthesis: a terminal triple bond toolbox.Nature chemical biology · 2015Article
- Diversity of Δ12 fatty acid desaturases in santalaceae and their role in production of seed oil acetylenic fatty acids.The Journal of biological chemistry · 2013Article
- A large and functionally diverse family of Fad2 genes in safflower (Carthamus tinctorius L.).BMC plant biology · 2013Article
- The convergent evolution of defensive polyacetylenic fatty acid biosynthesis genes in soldier beetles.Nature communications · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Acetylenic specialized metabolites containing one or more carbon-carbon triple bonds are widespread, being found in fungi, vascular and lower plants, marine sponges and algae, and insects. Plants, moss, and most recently, insects, have been shown to employ an energetically difficult, sequential dehydrogenation mechanism for acetylenic bond formation. Here, we describe the cloning and heterologous expression in yeast of a linoleoyl 12-desaturase (acetylenase) and a bifunctional desaturase with Delta(12)-/Delta(14)-regiospecificity from the Pacific golden chanterelle. The acetylenase gene, which is the first identified from a fungus, is phylogenetically distinct from known plant and fungal desaturases. Together, the bifunctional desaturase and the acetylenase provide the enzymatic activities required to drive oleate through linoleate to crepenynate and the conjugated enyne (14Z)-dehydrocrepenynate, the branchpoint precursors to a major class of acetylenic natural products.
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