ArticleJournal of cell science2010
Pax3 induces differentiation of juvenile skeletal muscle stem cells without transcriptional upregulation of canonical myogenic regulatory factors.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- PAX3: A Driver of Normal Development and Disease.Biomolecules · 2026Review
- Regulation and function of Pax3 in muscle stem cell heterogeneity and stress response.Journal of muscle research and cell motility · 2025Review
- An Enzyme-Free Method for Isolation and Expansion of Muscle Stem Cells for Cultivated Meat Applications.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Reductive stress impairs myogenic differentiation.Redox biology · 2020Article
- Impacts of the 1918 flu on survivors' nutritional status: A double quasi-natural experiment.PloS one · 2020Article
- Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche.Stem cell reports · 2019Article
- Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells.Stem cell reports · 2019Article
- Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice.The Journal of endocrinology · 2017Article
- Noggin inactivation affects the number and differentiation potential of muscle progenitor cells in vivo.Scientific reports · 2016Article
- Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls.Nature communications · 2015Article
- Extended 2D myotube culture recapitulates postnatal fibre type plasticity.BMC cell biology · 2015Article
- Satellite cells: regenerative mechanisms and applicability in muscular dystrophy.Stem cells international · 2015Review
- Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells.Free radical biology & medicine · 2014Article
- Transcriptional targets of Foxd3 in murine ES cells.Stem cell research · 2014Article
- Silencing Pax3 by shRNA inhibits the proliferation and differentiation of duck (Anas platyrhynchos) myoblasts.Molecular and cellular biochemistry · 2014Article
- In vitro indeterminate teleost myogenesis appears to be dependent on Pax3.In vitro cellular & developmental biology. Animal · 2013Article
- The origin and fate of muscle satellite cells.Stem cell reviews and reports · 2012Review
- Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration.Journal of cellular and molecular medicine · 2011Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Pax3 is an essential myogenic regulator of fetal and embryonic development, but its role in postnatal myogenesis remains a topic of debate. We show that constitutive expression of Pax3 in postnatal, juvenile mouse skeletal muscle stem cells, a subset of the heterogeneous satellite cell pool highly enriched for myogenic activity, potently induces differentiation. This differentiation-promoting activity stands in contrast to the differentiation-inhibiting effects of Pax3 in the commonly used mouse myoblast cell line C2C12. Pax3 mRNA levels in distinct muscles correlate with the rate of myogenic differentiation of their muscle stem cells. Although Pax3 controls embryonic myogenesis through regulation of the canonical myogenic regulatory factors (MRFs) Myf-5, MyoD, myogenin and Mrf4, we find that in postnatal muscle stem cells, ectopic Pax3 expression fails to induce expression of any of these factors. Unexpectedly, overexpression of neither Myf-5 nor myogenin is sufficient to induce differentiation of juvenile stem cells; and knockdown of Myf-5, rather than inhibiting differentiation, promotes it. Taken together, our results suggest that there are distinct myogenic regulatory pathways that control the embryonic development, juvenile myogenesis and adult regeneration of skeletal myofibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.