Evidence map›Paper›PMID 20605696›Full record

Trial reportNutrition (Burbank, Los Angeles County, Calif.)2011

Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome.

Arpita Basu, Mei Du, Karah Sanchez, Misti J Leyva, Nancy M Betts, Steve Blevins, Mingyuan Wu, Christopher E Aston, Timothy J Lyons

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition (Burbank, Los Angeles County, Calif.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  6. Green and black tea for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2013
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arpita BasuNutritional Sciences, Oklahoma State University, Stillwater, Oklahoma, USA. arpita.basu@okstate.edu
Mei Du
Karah Sanchez
Misti J Leyva
Nancy M Betts
Steve Blevins
Mingyuan Wu
Christopher E Aston
Timothy J Lyons

Funding

Trt. of Primary Hyperaldosteronism w/ACE Inhibitors &Angiotension Rec. BlockersM01RR014467 · NCRR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI TUCKER, PHEBE M · 2001 to 2007
$10.4M
NCRR NIH HHS M01 RR014467NCRR NIH HHS M01-RR14467
6 · The paper itself

Abstract

objectiveGreen tea (Camellia sinensis) has shown to exert cardioprotective benefits in observational studies. The objective of this clinical trial was to assess the effects of green tea on features of metabolic syndrome and inflammation in obese subjects.

methodsWe conducted a randomized controlled trial in obese subjects with metabolic syndrome. Thirty-five subjects [(mean ± SE) age 42.5 ± 1.7 y, body mass index 36.1 ± 1.3 kg/m(2)] completed the 8-wk study and were randomly assigned to receive green tea (4 cups/d), green tea extract (2 capsules and 4 cups water/d), or no treatment (4 cups water/d). Both the beverage and extract groups had similar dosing of epigallocatechin-3-gallate, the active green tea polyphenol. Fasting blood samples were collected at screening, 4 and 8 wk of the study.

resultsGreen tea beverage or extract supplementation did not significantly alter features of metabolic syndrome or biomarkers of inflammation including adiponectin, C-reactive protein, interleukin-6, interleukin-1β, soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1, leptin, or leptin:adiponectin ratio. However, both green tea beverage and extracts significantly reduced plasma serum amyloid alpha versus no treatment (P < 0.005).

conclusionThis study suggests that the daily consumption of green tea beverage or extracts for 8 wk was well tolerated but did not affect the features of metabolic syndrome. However, green tea significantly reduced plasma serum amyloid alpha, an independent cardiovascular disease risk factor, in obese subjects with metabolic syndrome.

Indexed as

PhytotherapyAdultAntioxidantsBiomarkersCamellia sinensisCardiovascular DiseasesCatechinC-Reactive ProteinFemaleHumansInflammationIntercellular Adhesion Molecule-1Interleukin-1betaInterleukin-6MaleMetabolic SyndromeAntioxidantsBiomarkersCatechinC-Reactive Proteinepigallocatechin gallateIntercellular Adhesion Molecule-1Interleukin-1betaInterleukin-6Plant ExtractsTeaVascular Cell Adhesion Molecule-1

Identifiers

PMID20605696
PMCPMC2952043

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.