ArticleVirology2010
Replication-independent activation of human plasmacytoid dendritic cells by the paramyxovirus SV5 Requires TLR7 and autophagy pathways.
Article in Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Role of autophagy in antiviral innate immunity.Cellular & molecular biology letters · 2026Review
- Review
- Canine distemper virus N protein induces autophagy to facilitate viral replication.BMC veterinary research · 2023Article
- Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis.Clinical and experimental immunology · 2022Review
- Regulation of Innate Immune Responses by Autophagy: A Goldmine for Viruses.Frontiers in immunology · 2020Review
- Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy.Journal of biomedical science · 2019Review
- Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation.Cell death and differentiation · 2019Review
- Review
- Autophagy in dendritic cells.Cellular & molecular immunology · 2018Review
- Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response.Frontiers in immunology · 2018Article
- Autophagy in Negative-Strand RNA Virus Infection.Frontiers in microbiology · 2018Review
- Article
- Article
- The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome.Frontiers in immunology · 2017Review
- Article
- Viruses and the autophagy pathway.Virology · 2015Review
- Toll-like receptors in antiviral innate immunity.Journal of molecular biology · 2014Review
- Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.PloS one · 2014Article
- Autophagy benefits the replication of Newcastle disease virus in chicken cells and tissues.Journal of virology · 2014Article
- Paramyxovirus activation and inhibition of innate immune responses.Journal of molecular biology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The paramyxovirus Simian Virus 5 (SV5) is a poor inducer of interferon (IFN) secretion in all cell types tested so far, including primary epithelial cells and primary human myeloid dendritic cells. SV5 is hypothesized to limit induction of antiviral responses through control of viral gene expression and production of the V protein antagonist. Plasmacytoid dendritic cells (pDCs) are known to uniquely express toll-like receptor (TLR)-7 and are a main producer of IFN-alpha among peripheral blood mononuclear cells in response to many viruses. Here, we tested whether SV5 would remain a poor inducer of IFN in primary human pDCs. The efficiency of SV5 infection of pDCs could be increased by an increasing multiplicity of infection. pDCs infected by both live and UV-inactivated SV5 induced large amounts of IFN-alpha secretion and resulted in upregulation of maturation markers CD80 and CD86. However, IL-6 secretion was not induced by SV5 infection. When TLR7 signaling was inhibited, SV5 induced less IFN secretion and CD80 expression, and there was a corresponding increase in number of infected cells. Similar effects were seen with inhibitors of cellular autophagy pathways, suggesting that the SV5 activation of pDC requires access to the cytoplasm and autophagic sampling of cytoplasmic contents. These results have implications for control of SV5 infections in vivo and for development of SV5 as a vaccine vector.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.