ArticleAtherosclerosis2010
Association of an allele on chromosome 9 and abdominal aortic aneurysm.
Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis.BMC medical genetics · 2012Pooled it
- Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression.PloS one · 2025Article
- Expression ratio of circular to linear ANRIL in hypertensive patients with coronary artery disease.Scientific reports · 2022Article
- The Role of ANRIL in Atherosclerosis.Disease markers · 2022Review
- Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm.International journal of molecular sciences · 2020Review
- Role of Circular RNAs in the Pathogenesis of Cardiovascular Disease.Journal of cardiovascular translational research · 2020Review
- Prevalence of Previously Undiagnosed Abdominal Aortic Aneurysms in Patients with Intracranial Aneurysms: From the Brain and Aortic Aneurysms Study (BAAS).Neurocritical care · 2020Article
- Analysis of the 9p21.3 sequence associated with coronary artery disease reveals a tendency for duplication in a CAD patient.Oncotarget · 2018Article
- Long non-coding RNA ANRIL in gene regulation and its duality in atherosclerosis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Review
- The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts.Age (Dordrecht, Netherlands) · 2014Article
- Association of arterial stiffness with single nucleotide polymorphism rs1333049 and metabolic risk factors.Cardiovascular diabetology · 2013Article
- Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk.Stroke · 2012Article
- Genomic research to identify novel pathways in the development of abdominal aortic aneurysm.Cardiology research and practice · 2012Article
- Pathophysiology and epidemiology of abdominal aortic aneurysms.Nature reviews. Cardiology · 2011Review
- Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.PLoS genetics · 2010Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveAbdominal aortic aneurysm (AAA) has been recognized as a multi-factorial disease with both genetic and environmental risk factors. A locus residing within non-coding DNA on chromosome 9p21.3 has recently been associated with AAA. To further investigate the significance of this site for AAA, we performed an association study on a large group of 3371 men aged 65-83 years of whom 513 had an AAA.
methodsAll men were assessed for other risk factors in a uniform way and an ultrasound of the abdominal aorta was performed.
resultsOur findings validated the strong association of the chromosome 9p21.3 SNPs rs10757278 and rs1333049 with AAA and demonstrated the upregulation of LINE-1 elements at the site of AAA.
conclusionThis study confirms a reproducible association between risk alleles on chromosome 9p21.3 and AAA. We also provide preliminary evidence for an association of LINE-1 elements with AAA which will require further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.