ArticleThe journal of gene medicine2010
Silk-elastinlike protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumors.
Article in The journal of gene medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Bioengineered elastin- and silk-biomaterials for drug and gene delivery.Advanced drug delivery reviews · 2020Pooled it
- Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance.Cancer metastasis reviews · 2023Review
- Polymeric Nanovectors Incorporated with Ganciclovir and HSV-Molecules (Basel, Switzerland) · 2021Article
- Cytokine-induced killer cells carrying recombinant oncolytic adenovirus expressing p21Ras scFv inhibited liver cancer.Journal of Cancer · 2021Article
- Silk Fibroin-Based Materials for Catalyst Immobilization.Molecules (Basel, Switzerland) · 2020Review
- Article
- Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging.Bioconjugate chemistry · 2018Article
- Rapidly responsive silk fibroin hydrogels as an artificial matrix for the programmed tumor cells death.PloS one · 2018Article
- Self-Assembly of Thermoresponsive Recombinant Silk-Elastinlike Nanogels.Macromolecular bioscience · 2018Article
- Evolving lessons on nanomaterial-coated viral vectors for local and systemic gene therapy.Nanomedicine (London, England) · 2016Review
- Vascular Accessibility of Endothelial Targeted Ferritin Nanoparticles.Bioconjugate chemistry · 2016Article
- Silk-elastin-like protein biomaterials for the controlled delivery of therapeutics.Expert opinion on drug delivery · 2015Review
- Gene-directed enzyme prodrug therapy.The AAPS journal · 2015Review
- Silk-based biomaterials for sustained drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Controlled release from recombinant polymers.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Oncolytic virotherapy of canine and feline cancer.Viruses · 2014Review
- Local sustained delivery of oncolytic adenovirus with injectable alginate gel for cancer virotherapy.Gene therapy · 2013Article
- Preparation and characterization of silk fibroin as a biomaterial with potential for drug delivery.Journal of translational medicine · 2012Article
- Comparison of silk-elastinlike protein polymer hydrogel and poloxamer in matrix-mediated gene delivery.International journal of pharmaceutics · 2012Article
- Elastomeric polypeptides.Topics in current chemistry · 2012Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAdenoviral-directed enzyme prodrug therapy is a promising approach for head and neck cancer gene therapy. The challenges faced by this approach, however, comprise transient gene expression and dissemination of viruses to distant organs.
methodsWe used recombinant silk-elastinlike protein polymer (SELP) matrices for intratumoral delivery of adenoviruses containing both thymidine kinase-1 and luciferase genes in a nude mouse model of JHU-022 head and neck tumor. Hydrogels made from two SELP analogues (47K and 815K), with similar silk to elastinlike block ratios but different block lengths, were studied for intratumoral viral delivery. Tumor-bearing mice were followed up for tumor progression and luciferase gene expression concomitantly for 5 weeks. Polymer safety was evaluated through body weight change, blood count, and liver and kidney functions, in addition to gross and microscopic histological examination.
resultsSELP-815K analogues efficiently controlled the duration and extent of transfection in tumors for up to 5 weeks with no detectable spread to the liver. An approximately five-fold greater reduction in tumor volume was obtained with matrix-mediated delivery compared to intra-tumoral injection of adenoviruses in saline. SELP matrix proved safe in all injected mice compared to the control group.
conclusionsThe SELP-controlled gene delivery approach could potentially improve the anticancer activity of virus-mediated gene therapy at the same time as limiting viral spread to normal organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.