ReviewNature reviews. Clinical oncology2010
Castleman's disease--a two compartment model of HHV8 infection.
Review in Nature reviews. Clinical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- Diagnostic challenge of human herpesvirus 8-associated multicentric Castleman disease in a patient living with HIV disease.BMJ case reports · 2026Article
- Snapshot Look at Castleman Disease.Journal of cellular and molecular medicine · 2026Review
- Article
- Transoral robotic surgery tongue base debulking in Castleman's disease.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Article
- Cytological diagnosis of hyaline-vascular type of Castleman disease.Autopsy & case reports · 2024Article
- Multicentric Castleman Disease of the Supraglottis: A Surgeons' Dilemma.Iranian journal of otorhinolaryngology · 2023Article
- Plasma Cell Gingivitis Treated with Photobiomodulation, with No Recurrence for a Five-Year Follow-Up.Case reports in dentistry · 2022Article
- Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis.Journal of clinical medicine · 2021Article
- Human Herpesvirus 8 and Lymphoproliferative Disorders.Mediterranean journal of hematology and infectious diseases · 2018Review
- The role of IL-6 in host defence against infections: immunobiology and clinical implications.Nature reviews. Rheumatology · 2017Review
- HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Castleman's disease at parotid gland.Journal of dental sciences · 2017Article
- Castleman's disease in carcinoma gall bladder.BMJ case reports · 2016Article
- Article
- Article
- Ill-defined germinal centers and severely reduced plasma cells are histological hallmarks of lymphadenopathy in patients with common variable immunodeficiency.Journal of clinical immunology · 2014Article
- Surgical Management of Unicentric Castleman's Disease in the Abdomen.Annals of coloproctology · 2014Article
- [Dyspnoea, cough and B symptoms in a 40-year-old woman].Der Internist · 2013Article
- Multicentric Castleman's disease: a challenging diagnosis.Pathology oncology research : POR · 2013Review
- Discordant lymphocyte-depleted classical Hodgkin's and peripheral T-cell lymphoma arising in a patient 11 years after diagnosis of multicentric Castleman's disease.International journal of hematology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Castleman's disease is a primary infectious disease of the lymph node that causes local symptoms or a systemic inflammatory syndrome. Histopathology reveals a destroyed lymph node architecture that can range from hyaline-vascular disease to plasma-cell disease. Viral interleukin 6 (vIL-6) produced during the replication of human herpesvirus type 8 (HHV8) is the key driver of systemic inflammation and cellular proliferation. Stage progression of Castleman's disease results from switches between viral latency and lytic replication, and lymphatic and hematogenous spread. Multicentric plasma-cell disease in HIV-1 patients is associated with HHV8 infection. Polyclonal plasmablast proliferation escapes control in the germinal center with eventual malignant transformation into non-Hodgkin lymphoma. Surgery produces excellent results in unicentric disease, while multicentric disease responds to anti-CD20 therapy or IL-6 and chemotherapy. Lymphovascular endothelium and naive B cells are infectious reservoir-opening options for antiangiogenic and anti-CD19 strategies to enhance outcomes in patients with systemic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.