ArticleNeurology2010
Alzheimer disease identification using amyloid imaging and reserve variables: proof of concept.
Article in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02141971 (Down Syndrome Biomarker Initiative), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Down Syndrome Biomarker Initiative: A Natural History Study of Alzheimer's Disease in Down Syndrome (Pilot Study)
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive Reserve in Healthy Aging and Alzheimer's Disease: A Meta-Analysis of fMRI Studies.American journal of Alzheimer's disease and other dementias · 2016Pooled it
- Pooled it
- In vivo assessment of amyloid-β deposition in nondemented very elderly subjects.Annals of neurology · 2013Trial
- Human iPSC-derived retinal organoids develop robust Alzheimer's disease neuropathology.Frontiers in cellular neuroscience · 2024Article
- Quantifying and Examining Reserve in Symptomatic Former National Football League Players.Journal of Alzheimer's disease : JAD · 2022Article
- Novel Functions of the Neurodegenerative-Related Gene Tau in Cancer.Frontiers in aging neuroscience · 2019Article
- Persistence of Gender Related-Effects on Visuo-Spatial and Verbal Working Memory in Right Brain-Damaged Patients.Frontiers in behavioral neuroscience · 2016Article
- Does bilingualism contribute to cognitive reserve? Cognitive and neural perspectives.Neuropsychology · 2015Review
- Cognitive reserve and clinical expression of Alzheimer's disease: evidence and implications for brain PET imaging.American journal of nuclear medicine and molecular imaging · 2014Article
- Neuroimaging of dementia in 2013: what radiologists need to know.European radiology · 2013Review
- Article
- The Alzheimer's disease-8 and Montreal Cognitive Assessment as screening tools for neurocognitive impairment in HIV-infected persons.Journal of neurovirology · 2013Article
- A European multicentre PET study of fibrillar amyloid in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2013Article
- Promising developments in neuropsychological approaches for the detection of preclinical Alzheimer's disease: a selective review.Alzheimer's research & therapy · 2013Review
- Neuropsychological test performance and cognitive reserve in healthy aging and the Alzheimer's disease spectrum: a theoretically driven factor analysis.Journal of the International Neuropsychological Society : JINS · 2012Article
- Education and occupation provide reserve in both ApoE ε4 carrier and noncarrier patients with probable Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Article
- OPTIMIZING DIAGNOSIS AND MANANGEMENT IN MILD-TO-MODERATE ALZHEIMER'S DISEASE.Neurodegenerative disease management · 2012Article
- Cardiac sympathetic neuroimaging in dementia with lewy bodies.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2012Article
- Brain imaging in Alzheimer disease.Cold Spring Harbor perspectives in medicine · 2012Review
- PET amyloid-beta imaging in preclinical Alzheimer's disease.Biochimica et biophysica acta · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveSeveral factors may influence the relationship between Alzheimer disease (AD) lesions and the expression of dementia, including those related to brain and cognitive reserve. Other factors may confound the association between AD pathology and dementia. We tested whether factors thought to influence the association of AD pathology and dementia help to accurately identify dementia of the Alzheimer type (DAT) when considered together with amyloid imaging.
methodsParticipants with normal cognition (n = 180) and with DAT (n = 25), aged 50 years or older, took part in clinical, neurologic, and psychometric assessments. PET with the Pittsburgh compound B (PiB) tracer was used to measure brain amyloid, yielding a mean cortical binding potential (MCBP) reflecting PiB uptake. Logistic regression was used to generate receiver operating characteristic curves, and the areas under those curves (AUC), to compare the predictive accuracy of using MCBP alone vs MCBP together with other variables selected using a stepwise selection procedure to identify participants with DAT vs normal cognition.
resultsThe AUC resulting from MCBP alone was 0.84 (95% confidence interval [CI] = 0.73-0.94; cross-validated AUC = 0.80, 95% CI = 0.68-0.92). The AUC for the predictive equation generated by a stepwise model including education, normalized whole brain volume, physical health rating, gender, and use of medications that may interfere with cognition was 0.94 (95% CI = 0.90-0.98; cross-validated AUC = 0.91, 95% CI = 0.85-0.96), an improvement (p = 0.025) over that yielded using MCBP alone.
conclusionResults suggest that factors reported to influence associations between AD pathology and dementia can improve the predictive accuracy of amyloid imaging for the identification of symptomatic AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.