ArticleThe Journal of physiology2010
Effect of volume loading on the Frank-Starling relation during reductions in central blood volume in heat-stressed humans.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Coagulation competence for predicting perioperative hemorrhage in patients treated with lactated Ringer's vs. Dextran--a randomized controlled trial.BMC anesthesiology · 2015Trial
- Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Sweat loss during heat stress contributes to subsequent reductions in lower-body negative pressure tolerance.Experimental physiology · 2013Trial
- Colloid volume loading does not mitigate decreases in central blood volume during simulated haemorrhage while heat stressed.The Journal of physiology · 2012Trial
- Systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from passive heat stress in young and older adults.Physiological reports · 2025Article
- The Acute Effect of Hot Water Immersion on Cardiac Function in Individuals with Cervical Spinal Cord Injury.Journal of clinical medicine · 2024Article
- Compensatory reserve index during central hypovolemia and volume loading in healthy young and older hyperthermic adults: A pilot study.Physiological reports · 2024Article
- Combining hypoxia with thermal stimuli in humans: physiological responses and potential sex differences.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Review
- Cardiovascular responses to hot skin at rest and during exercise.Temperature (Austin, Tex.) · 2023Review
- Heat therapy: mechanistic underpinnings and applications to cardiovascular health.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults.The Journal of physiology · 2017Article
- Healthy aging does not compromise the augmentation of cardiac function during heat stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
- The role of cardiac sympathetic innervation and skin thermoreceptors on cardiac responses during heat stress.American journal of physiology. Heart and circulatory physiology · 2015Article
- Sympathetic activity during passive heat stress in healthy aged humans.The Journal of physiology · 2015Article
- Human cardiovascular responses to passive heat stress.Comprehensive Physiology · 2015Review
- The effects of cold and lower body negative pressure on cardiovascular homeostasis.BioMed research international · 2015Article
- Beneficial effects of elevating cardiac preload on left-ventricular diastolic function and volume during heat stress: implications toward tolerance during a hemorrhagic insult.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Hypercoagulability in response to elevated body temperature and central hypovolemia.The Journal of surgical research · 2013Article
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
During reductions in central blood volume while heat stressed, a greater decrease in stroke volume (SV) for a similar decrease in ventricular filling pressure, compared to normothermia, suggests that the heart is operating on a steeper portion of a Frank-Starling curve. If so, volume loading of heat-stressed individuals would shift the operating point to a flatter portion of the heat stress Frank-Starling curve thereby attenuating the reduction in SV during subsequent decreases in central blood volume. To investigate this hypothesis, right heart catheterization was performed in eight males from whom pulmonary capillary wedge pressure (PCWP), central venous pressure and SV (via thermodilution) were obtained while central blood volume was reduced via lower-body negative pressure (LBNP) during normothermia, whole-body heating (increase in blood temperature 1 degrees C), and during whole-body heating after intravascular volume expansion. Volume expansion was accomplished by administration of a combination of a synthetic colloid (HES 130/0.4, Voluven) and saline. Before LBNP, SV was not affected by heating (122 +/- 30 ml; mean +/- s.d.) compared to normothermia (110 +/- 20 ml; P = 0.06). However, subsequent volume loading increased SV to 143 +/- 29 ml (P = 0.003). LBNP provoked a larger decrease in SV relative to the decrease in PCWP during heating (8.6 +/- 1.9 ml mmHg(1)) compared to normothermia (4.5 +/- 3.0 ml mmHg(1), P = 0.02). After volume loading while heat stressed, the reduction in the SV to PCWP ratio during LBNP was comparable to that observed during normothermia (4.8 +/- 2.3 ml mmHg(1); P = 0.78). These data support the hypothesis that a Frank-Starling mechanism contributes to compromised blood pressure control during simulated haemorrhage in heat-stressed individuals, and extend those findings by showing that volume infusion corrects this deficit by shifting the operating point to a flatter portion of the heat stress Frank-Starling curve.
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