ArticleGastroenterology2010
FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice.
Article in Gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review.Scientific reports · 2021Pooled it
- Markers of liver regeneration-the role of growth factors and cytokines: a systematic review.BMC surgery · 2020Pooled it
- The role of fibroblast growth factors in cell and cancer metabolism.FEBS letters · 2026Review
- LincRNA-p21: A Double-Edged Sword in Ethanol-Induced Liver Damage and Its Nanoparticle Solution.International journal of nanomedicine · 2026Article
- βCell death & disease · 2022Article
- Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis.iScience · 2021Article
- Insulin resistance disrupts epithelial repair and niche-progenitor Fgf signaling during chronic liver injury.PLoS biology · 2019Article
- Fibroblast growth factor receptor 1 antagonism attenuates lipopolysaccharide-induced activation of hepatic stellate cells via suppressing inflammation.Experimental and therapeutic medicine · 2018Article
- Key Anti-Fibrosis Associated Long Noncoding RNAs Identified in Human Hepatic Stellate Cell via Transcriptome Sequencing Analysis.International journal of molecular sciences · 2018Article
- FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.Development (Cambridge, England) · 2016Article
- Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats.World journal of gastroenterology · 2015Article
- Sinusoidal endothelial cells direct traffic at the intersection of regeneration and fibrosis.Hepatology (Baltimore, Md.) · 2014Article
- Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent β-catenin activation.Journal of hepatology · 2014Article
- Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.Nature · 2014Article
- Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish.Transgenic research · 2013Article
- FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.Genes & development · 2013Article
- Fructose protects murine hepatocytes from tumor necrosis factor-induced apoptosis by modulating JNK signaling.The Journal of biological chemistry · 2012Article
- Article
- Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease.Journal of biochemistry · 2011Review
- Regulation of liver regeneration by growth factors and cytokines.EMBO molecular medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
BACKGROUND &
aimsFibroblast growth factor receptor 4 (FGFR4) controls bile acid metabolism and protects the liver from fibrosis, but the roles of FGFR1 and FGFR2 in the adult liver are largely unknown. We investigated the functions and mechanisms of action of these receptors in liver homeostasis, regeneration, and fibrosis.
methodsWe generated mice with hepatocytes that lack FGFR1 and FGFR2 and subjected them to acute and chronic carbon tetrachloride-induced liver injury and partial hepatectomy; mice were also injected with FGF7. We performed histology, histomorphometry, real-time reverse transcription polymerase chain reaction, and immunoblot analyses.
resultsIn hepatocytes, loss of FGFR1 and FGFR2 eliminated responsiveness to FGF7 and related FGF family members but did not affect toxin-induced liver injury and fibrosis. However, mortality after partial hepatectomy increased because of severe hepatocyte necrosis. These effects appeared to be mediated by a failure of hepatocytes to induce the expression of the transcriptional regulators Dbp and Tef upon liver surgery; this affected expression of their target genes, which encode detoxifying cytochrome P450 enzymes. We found that Dbp and Tef expression was directly controlled by FGFR signaling in hepatocytes. As a consequence of the reduced expression of genes that control detoxification, the liver tissue that remained after partial hepatectomy failed to efficiently metabolize endogenous compounds and the drugs applied for anesthesia/analgesia.
conclusionsWe identified a new, cytoprotective effect of FGFR1 and FGFR2 in the regenerating liver and suggest the use of recombinant FGF7 to increase survival of patients after surgical resection of large amounts of liver tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.