ArticleMolecular cell2010
E. coli SbcCD and RecA control chromosomal rearrangement induced by an interrupted palindrome.
Article in Molecular cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- How DNA secondary structures drive replication fork instability.DNA repair · 2025Review
- Article
- Assessment and Mitigation of CRISPR-Cas9-Induced Nontargeted Translocations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A 69.9-kb long inverted repeat increases genome instability in a strain ofNAR genomics and bioinformatics · 2025Article
- Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism.Nature communications · 2023Article
- Widely spaced and divergent inverted repeats become a potent source of chromosomal rearrangements in long single-stranded DNA regions.Nucleic acids research · 2023Article
- Structural parameters of palindromic repeats determine the specificity of nuclease attack of secondary structures.Nucleic acids research · 2021Article
- A reference catalog of DNA palindromes in the human genome and their variations in 1000 Genomes.Human genome variation · 2020Article
- Review
- A curious new role for MRN in Schizosaccharomyces pombe non-homologous end-joining.Current genetics · 2018Review
- SbcC-SbcD and ExoI process convergent forks to complete chromosome replication.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Review
- Expressed Structurally Stable Inverted Duplicates in Mammalian Genomes as Functional Noncoding Elements.Genome biology and evolution · 2017Article
- Unprecedented large inverted repeats at the replication terminus of circular bacterial chromosomes suggest a novel mode of chromosome rescue.Scientific reports · 2017Article
- ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex.The EMBO journal · 2016Article
- A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex.Nucleic acids research · 2015Article
- Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification.Molecular cell · 2015Article
- Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.The EMBO journal · 2014Article
- A perfect palindrome in the Escherichia coli chromosome forms DNA hairpins on both leading- and lagging-strands.Nucleic acids research · 2014Article
- Structural studies of DNA end detection and resection in homologous recombination.Cold Spring Harbor perspectives in biology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Survival and genome stability are critical characteristics of healthy cells. DNA palindromes pose a threat to genome stability and have been shown to participate in a reaction leading to the formation of inverted chromosome duplications centered around themselves. There is considerable interest in the mechanism of this rearrangement given its likely contribution to genome instability in cancer cells. This study shows that formation of large inverted chromosome duplications can be observed in the chromosome of Escherichia coli. They are formed at the site of a 246 bp interrupted DNA palindrome in the absence of the hairpin nuclease SbcCD and the recombination protein RecA. The genetic requirements for this spontaneous rearrangement are consistent with a pathway involving DNA degradation and hairpin formation, as opposed to a cruciform cleavage pathway. Accordingly, the formation of palindrome-dependent hairpin intermediates can be induced by an adjacent DNA double-stand break.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.