ArticleCell2010
D'oh! genes and environment cause Crohn's disease.
Article in Cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Renal Toxicity.Advances in experimental medicine and biology · 2021Review
- The signaling axis of microRNA-31/interleukin-25 regulates Th1/Th17-mediated inflammation response in colitis.Mucosal immunology · 2017Article
- Gene-gene and gene-environment interactions in apolipoprotein L1 gene-associated nephropathy.Clinical journal of the American Society of Nephrology : CJASN · 2014Review
- Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes.Immunotherapy · 2013Review
- Dysregulation of immune homeostasis in autoimmune diseases.Nature medicine · 2012Article
- Redefining disease.Clinical medicine (London, England) · 2010Review
- Ten years of genetics and genomics: what have we achieved and where are we heading?Nature reviews. Genetics · 2010Review
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Information obtained from genome-wide association studies has cracked open the biology of common chronic diseases by identifying genes that predispose individuals to these disorders. Cadwell et al. (2010) now demonstrate that a viral infection, a toxic insult to the gut, commensal bacteria, and a Crohn's disease susceptibility gene collude to cause inflammatory disease in the mouse gut.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.