ArticleBMC medical genetics2010
Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Genomic dissection of sleep archetypes in a large autism cohort.medRxiv : the preprint server for health sciences · 2025Article
- Requirement of hippocampal DG nNOS-CAPON dissociation for the anxiolytic and antidepressant effects of fluoxetine.Theranostics · 2022Article
- Placental DNA methylation changes and the early prediction of autism in full-term newborns.PloS one · 2021Article
- nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety.British journal of pharmacology · 2020Article
- Tau binding protein CAPON induces tau aggregation and neurodegeneration.Nature communications · 2019Article
- Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder.Translational psychiatry · 2019Article
- Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior.Frontiers in behavioral neuroscience · 2017Article
- NOS1AP O-GlcNAc Modification Involved in Neuron Apoptosis Induced by Excitotoxicity.International journal of molecular sciences · 2015Article
- Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder.Frontiers in physiology · 2015Article
- Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects.Frontiers in physiology · 2015Review
- Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling.Frontiers in cellular neuroscience · 2014Review
- Treatments for biomedical abnormalities associated with autism spectrum disorder.Frontiers in pediatrics · 2014Review
- Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study.Translational psychiatry · 2013Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gene encoding carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (NOS1AP) is located on chromosome 1q23.3, a candidate region for schizophrenia, autism spectrum disorders (ASD) and obsessive-compulsive disorder (OCD). Previous genetic and functional studies explored the role of NOS1AP in these psychiatric conditions, but only a limited number explored the sequence variability of NOS1AP.
methodsWe analyzed the coding sequence of NOS1AP in a large population (n = 280), including patients with schizophrenia (n = 72), ASD (n = 81) or OCD (n = 34), and in healthy volunteers controlled for the absence of personal or familial history of psychiatric disorders (n = 93).
resultsTwo non-synonymous variations, V37I and D423N were identified in two families, one with two siblings with OCD and the other with two brothers with ASD. These rare variations apparently segregate with the presence of psychiatric conditions.
conclusionsCoding variations of NOS1AP are relatively rare in patients and controls. Nevertheless, we report the first non-synonymous variations within the human NOS1AP gene that warrant further genetic and functional investigations to ascertain their roles in the susceptibility to psychiatric disorders.
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