ArticleFibrogenesis & tissue repair2010
Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis.
Article in Fibrogenesis & tissue repair, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Bidirectional influences and clinical implications of psychological factors and oral health during orthodontic treatment.The Saudi dental journal · 2026Review
- Serum amyloid P component suppresses melanoma growth and metastasis by inhibiting CCL1 secretion from macrophages.American journal of cancer research · 2026Article
- SAP deletion promotes malignant insulinoma progression by inducing CXCL12 secretion from CAFs via the CXCR4/p38/ERK signalling pathway.Journal of cellular and molecular medicine · 2024Article
- SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis.Journal of advanced research · 2023Article
- Inhibitors of the Sialidase NEU3 as Potential Therapeutics for Fibrosis.International journal of molecular sciences · 2022Review
- Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice.PloS one · 2021Article
- Multiple Functions of Lysyl Oxidase Like-2 in Oral Fibroproliferative Processes.Journal of dental research · 2018Article
- The Development of Serum Amyloid P as a Possible Therapeutic.Frontiers in immunology · 2018Review
- Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice.International journal of molecular medicine · 2017Article
- Serum Amyloid P-Component Prevents Cardiac Remodeling in Hypertensive Heart Disease.Journal of cardiovascular translational research · 2015Article
- Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease.Alimentary pharmacology & therapeutics · 2015Article
- Mechanisms of cellular fibrosis associated with cancer regimen-related toxicities.Frontiers in pharmacology · 2014Review
- Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.PloS one · 2014Article
- New approaches to modulating idiopathic pulmonary fibrosis.Current allergy and asthma reports · 2013Review
- FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.Journal of leukocyte biology · 2012Article
- Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology.Neurochemical research · 2012Article
- Swallowing dysfunction in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Review
- Curcumin mediates both dilation and constriction of peripheral arterioles via adrenergic receptors.The Journal of investigative dermatology · 2011Article
- Prevention and management of antineoplastic therapy induced oral mucositis.National journal of maxillofacial surgery · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effect of the anti-fibrotic protein serum amyloid P (SAP) on radiation-induced oral mucositis (OM) and fibrosis in a hamster cheek-pouch model. EXPERIMENTAL
designHamsters received a single dose of radiation (40 Gy) to the left everted cheek pouch to induce significant OM. The protective therapeutic potential of SAP was evaluated using varying dosing regimens. The extent of OM was measured using a validated six-point scoring scheme ranging from 0 (normal tissue, no mucositis) to 5 (complete ulceration). Fibrotic remodeling was also visualized histologically and quantified at later time points using collagen gene expression.
resultsSAP treatment attenuated the profile of radiation-induced oral mucositis by delaying the time of onset, reducing the peak value, and enhancing the resolution of injury. The peak mucositis score was reduced by approximately 0.5 grade in SAP-treated animals. The number of animal days with a score of >/= 3 was reduced by 48% in the SAP-treated group, compared with the saline control group (P < 0.01). SAP also inhibited the extent of tissue remodeling and decreased radiation-induced increases in myofibroblast number. Attenuated collagen deposition and gene expression was also observed in the cheek pouches of hamsters treated with SAP at both 16 and 28 days post-radiation.
conclusionsSAP treatment significantly attenuated radiation-induced injury. In particular, SAP attenuated the severity of OM and inhibited pathogenic remodeling. This suggests that SAP may be a useful therapy for the palliation of side effects observed during treatment for head and neck cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.