ReviewFEMS immunology and medical microbiology2010
Vaccine development in Staphylococcus aureus: taking the biofilm phenotype into consideration.
Review in FEMS immunology and medical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Safety and immunogenicity of a novel Staphylococcus aureus vaccine: results from the first study of the vaccine dose range in humans.Clinical and vaccine immunology : CVI · 2010Trial
- Article
- Global challenges and microbial biofilms: Identification of priority questions in biofilm research, innovation and policy.Biofilm · 2024Article
- The pathogenicity and virulence of the opportunistic pathogenVirulence · 2024Review
- The incidence of VP shunt infection in a middle-income nation: a retrospective analysis of a pediatric population.Frontiers in surgery · 2023Article
- Biofilm Formation by Pathogenic Bacteria: Applying aPathogens (Basel, Switzerland) · 2022Review
- Review
- Anti-Proliferative and Anti-Biofilm Potentials of Bacteriocins Produced by Non-Pathogenic Enterococcus sp.Probiotics and antimicrobial proteins · 2021Article
- Genomic Characterization of a New Biofilm-Forming and Adhesive ST398 Human-Adapted MSSA Lineage Causing Septic Knee Arthritis Following Surgical Reconstruction.Microorganisms · 2021Article
- Novel Treatments and Preventative Strategies Against Food-Poisoning Caused by Staphylococcal Species.Pathogens (Basel, Switzerland) · 2021Review
- Highly Efficient Antimicrobial and Antifouling Surface Coatings with Triclosan-Loaded Nanogels.ACS applied materials & interfaces · 2020Article
- CxxC Zinc Finger Protein Derived Peptide, MF18 Functions Against Biofilm Formation.The protein journal · 2020Article
- Comparative proteomic and genomic analyses of Brucella abortus biofilm and planktonic cells.Molecular medicine reports · 2020Article
- Clearance of Staphylococcus aureus fromInfection and immunity · 2019Article
- Article
- Staphylococcal Biofilms.Microbiology spectrum · 2018Review
- Electron Beam Immobilization of Novel Antimicrobial, Short Peptide Motifs Leads to Membrane Surfaces with Promising Antibacterial Properties.Journal of functional biomaterials · 2018Article
- Stress Tolerance-Related Genetic Traits of Fish PathogenFrontiers in microbiology · 2018Article
- [The significance of biofilm for the treatment of infections in orthopedic surgery : 2017 Update].Der Unfallchirurg · 2017Review
- Complete Genome Sequence ofGenome announcements · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Vaccine development against pathogenic bacteria is an imperative initiative as bacteria are gaining resistance to current antimicrobial therapies and few novel antibiotics are being developed. Candidate antigens for vaccine development can be identified by a multitude of high-throughput technologies that were accelerated by access to complete genomes. While considerable success has been achieved in vaccine development against bacterial pathogens, many species with multiple virulence factors and modes of infection have provided reasonable challenges in identifying protective antigens. In particular, vaccine candidates should be evaluated in the context of the complex disease properties, whether planktonic (e.g. sepsis and pneumonia) and/or biofilm associated (e.g. indwelling medical device infections). Because of the phenotypic differences between these modes of growth, those vaccine candidates chosen only for their efficacy in one disease state may fail against other infections. This review will summarize the history and types of bacterial vaccines and adjuvants as well as present an overview of modern antigen discovery and complications brought about by polymicrobial infections. Finally, we will also use one of the better studied microbial species that uses differential, multifactorial protein profiles to mediate an array of diseases, Staphylococcus aureus, to outline some of the more recently identified problematic issues in vaccine development in this biofilm-forming species.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.