ArticleMolecular biology reports2011
DNA damage and repair in endometrial cancer in correlation with the hOGG1 and RAD51 genes polymorphism.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 8 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 8 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Association of the hOGG1 Ser326Cys polymorphism with gynecologic cancer susceptibility: a meta-analysis.Bioscience reports · 2020Pooled it
- Association between RAD51 135 G/C polymorphism and risk of 3 common gynecological cancers: A meta-analysis.Medicine · 2018Pooled it
- Human 8-oxoguanine DNA glycosylase gene polymorphism (Ser326Cys) and cancer risk: updated meta-analysis.Oncotarget · 2017Pooled it
- A systematic review and meta-analysis of the association between OGG1 Ser326Cys polymorphism and cancers.Medical oncology (Northwood, London, England) · 2015Pooled it
- Genetic 135G/C polymorphism of RAD51 gene and risk of cancer: a meta-analysis of 28,956 cases and 28,372 controls.Familial cancer · 2014Pooled it
- Pooled it
- Association between the RAD51 135 G>C polymorphism and risk of cancer: a meta-analysis of 19,068 cases and 22,630 controls.PloS one · 2013Pooled it
- The effect of hOGG1 Ser326Cys polymorphism on cancer risk: evidence from a meta-analysis.PloS one · 2011Pooled it
- Advances in the Pathophysiology of Thin Endometrium.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review).Molecular medicine reports · 2025Review
- The association between inefficient repair of oxidative DNA lesions and common polymorphisms of the key base excision repair genes as well as their expression levels in patients with rheumatoid arthritis.Archives of medical science : AMS · 2025Article
- Polymorphisms of DNA Repair Genes in Thyroid Cancer.International journal of molecular sciences · 2024Review
- XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis.Open medicine (Warsaw, Poland) · 2024Review
- Using BioPAX-Parser (BiP) to enrich lists of genes or proteins with pathway data.BMC bioinformatics · 2021Article
- Associations between Genetically Predicted Circulating Protein Concentrations and Endometrial Cancer Risk.Cancers · 2021Article
- Endometrial cancer: a genetic point of view.Translational cancer research · 2020Article
- Association between single nucleotide polymorphism of DNA repair genes and endometrial cancer: a case-control study.International journal of clinical and experimental pathology · 2018Article
- Analysis of DNA Repair Genes Polymorphisms in Breast Cancer.Pathology oncology research : POR · 2017Article
- Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers.Oncotarget · 2016Article
- Association between the OGG1 Ser326Cys Polymorphism and Cancer Risk: Evidence from 152 Case-Control Studies.Journal of Cancer · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular reaction to the DNA-damaging agents may modulate individual's cancer susceptibility. This reaction is mainly determined by the efficacy of DNA repair, which in turn, may be influenced by the variability of DNA repair genes, expressed by their polymorphism. The hOGG1 gene encodes a glycosylase of base excision repair and RAD51 specifies a key protein in homologues recombination repair. Both proteins can be involved in the repair of DNA lesions, which are known to contribute to endometrial cancer. In the present work we determined the extent of basal DNA damage and the efficacy of removal of DNA damage induced by hydrogen peroxide and N-methyl-N'-nitro N-nitrosoguanidyne (MNNG) in peripheral blood lymphocytes of 30 endometrial cancer patients and 30 individuals without cancer. The results from DNA damage and repair study were correlated with the genotypes of two common polymorphisms of the hOGG1 and RAD51 genes: a G>C transversion at 1245 position of the hOGG1 gene producing a Ser → Cys substitution at the codon 326 (the Ser326Cys polymorphism) and a G>C substitution at 135 position of the RAD51 gene (the 135G>C polymorphism). DNA damage and repair were evaluated by alkaline single cell gel electrophoresis and genotypes were determined by restriction fragment length polymorphism PCR. We observed a strong association between endometrial cancer and the C/C genotype of the 135G>C polymorphism of the RAD51 gene. Moreover, there was a strong correlation between that genotype and endometrial cancer occurrence in subjects with a high level of basal DNA damage. We did not observe any correlation between the Ser326Cys polymorphism of the hOGG1 gene and endometrial cancer. Our result suggest that the 135G>C polymorphism of the RAD51 gene may be linked to endometrial cancer and can be considered as an additional marker of this disease.
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