ArticleChromosoma2010
Gene density profile reveals the marking of late replicated domains in the Drosophila melanogaster genome.
Article in Chromosoma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Heterogeneity of Brain Ribosomal Genes Expression Following Positive Fighting Experience in Male Mice as Revealed by RNA-Seq.Molecular neurobiology · 2018Article
- Similarity in replication timing between polytene and diploid cells is associated with the organization of the Drosophila genome.PloS one · 2018Article
- Functional dissection of Drosophila melanogaster SUUR protein influence on H3K27me3 profile.Epigenetics & chromatin · 2017Article
- Computer Analysis of Glioma Transcriptome Profiling: Alternative Splicing Events.Journal of integrative bioinformatics · 2017Article
- Protein and Genetic Composition of Four Chromatin Types inCurrent genomics · 2017Article
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- DNA replication in nurse cell polytene chromosomes of Drosophila melanogaster otu mutants.Chromosoma · 2015Article
- Underreplicated regions in Drosophila melanogaster are enriched with fast-evolving genes and highly conserved noncoding sequences.Genome biology and evolution · 2014Article
- DNA replication and transcription programs respond to the same chromatin cues.Genome research · 2014Article
- Developmental variation of the SUUR protein binding correlates with gene regulation and specific chromatin types in D. melanogaster.Chromosoma · 2014Article
- Genetic organization of interphase chromosome bands and interbands in Drosophila melanogaster.PloS one · 2014Article
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- Late replication domains in polytene and non-polytene cells of Drosophila melanogaster.PloS one · 2012Article
- Identical functional organization of nonpolytene and polytene chromosomes in Drosophila melanogaster.PloS one · 2011Article
- [Regulation of DNA replication timing].Molekuliarnaia biologiiaReview
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of replication timing has been a focus of many studies. It has been shown that numerous chromosomal regions switch their replication timing on cell differentiation in Drosophila and mice. However, it is not clear which features of these regions are essential for such regulation. In this study, we examined the organization of late underreplicated regions (URs) of the Drosophila melanogaster genome. When compared with their flanks, these regions showed decreased gene density. A detailed view revealed that these regions originate from unusual combination of short genes and long intergenic spacers. Furthermore, gene expression study showed that this pattern is mostly contributed by short testis-specific genes abundant in the URs. Based on these observations, we developed a genome scanning algorithm and identified 110 regions possessing similar gene density and transcriptional profiles. According to the published data, replication of these regions has been significantly shifted towards late S-phase in two Drosophila cell lines and in polytene chromosomes. Our results suggest that genomic organization of the underreplicated areas of Drosophila polytene chromosomes may be associated with the regulation of their replication timing.
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