ArticleExperimental brain research2010
Genetic regulation of microglia activation, complement expression, and neurodegeneration in a rat model of traumatic brain injury.
Article in Experimental brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Dysregulation of complement system in neuropsychiatric disorders: A mini review.Biomarkers in neuropsychiatry · 2022Article
- Microglia dynamics in adolescent traumatic brain injury.Journal of neuroinflammation · 2020Review
- Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma.Journal of neurotrauma · 2020Article
- Article
- Complement After Trauma: Suturing Innate and Adaptive Immunity.Frontiers in immunology · 2018Review
- Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ.Journal of neuroinflammation · 2016Article
- Could Intrathymic Injection of Myelin Basic Protein Suppress Inflammatory Response After Co-culture of T Lymphocytes and BV-2 Microglia Cells?Chinese medical journal · 2016Article
- Lesion Size Is Exacerbated in Hypoxic Rats Whereas Hypoxia-Inducible Factor-1 Alpha and Vascular Endothelial Growth Factor Increase in Injured Normoxic Rats: A Prospective Cohort Study of Secondary Hypoxia in Focal Traumatic Brain Injury.Frontiers in neurology · 2016Article
- Beneficial effects of hyperbaric oxygen on edema in rat hippocampus following traumatic brain injury.Experimental brain research · 2015Article
- Deficiency of complement receptors CR2/CR1 in Cr2⁻/⁻ mice reduces the extent of secondary brain damage after closed head injury.Journal of neuroinflammation · 2014Article
- Lipoic acid treatment after brain injury: study of the glial reaction.Clinical & developmental immunology · 2013Article
- Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury.Journal of neurotrauma · 2012Article
- Experimental animal models for studies on the mechanisms of blast-induced neurotrauma.Frontiers in neurology · 2012Article
- Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?British journal of pharmacology · 2011Review
- Susceptibility to Oxidative Stress Is Determined by Genetic Background in Neuronal Cell Cultures.eNeuroArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary brain damage following traumatic brain injury in part depends on neuroinflammation, a process where genetic factors may play an important role. We examined the response to a standardized cortical contusion in two different inbred rat strains, Dark Agouti (DA) and Piebald Virol Glaxo (PVG). Both are well characterized in models of autoimmune neuroinflammation, where DA is susceptible and PVG resistant. We found that infiltration of polymorphonuclear granulocytes (PMN) at 3-day postinjury was more pronounced in PVG. DA was more infiltrated by T cells at 3-day postinjury, showed an enhanced glial activation at 7-day postinjury and higher expression of C3 complement at 7-day postinjury. Neurodegeneration, assessed by Fluoro-Jade, was also more pronounced in the DA strain at 30-day postinjury. These results demonstrate differences in the response to cortical contusion injury attributable to genetic influences and suggest a link between injury-induced inflammation and neurodegeneration. Genetic factors that regulate inflammation elicited by brain trauma may be important for the development of secondary brain damage.
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