ArticleExperimental brain research2010
Retinal lesions induce layer-specific Fos expression changes in cat area 17.
Article in Experimental brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Visual system plasticity in mammals: the story of monocular enucleation-induced vision loss.Frontiers in systems neuroscience · 2015Review
- Homeostatic structural plasticity can account for topology changes following deafferentation and focal stroke.Frontiers in neuroanatomy · 2014Article
- A simple rule for dendritic spine and axonal bouton formation can account for cortical reorganization after focal retinal lesions.PLoS computational biology · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative analysis of the neuronal activity marker Fos revealed activity-dependent and lamina-specific changes in adult cat area 17, 14 days to 1 month after the induction of central retinal lesions. The supra- and infragranular layers were clearly differently engaged in the response to the visual deprivation, both inside and outside the lesion projection zone. The center of the LPZ exhibited an activity decrease in the extragranular layers, which was mainly reflected by an intracellular down-regulation of Fos rather than a decline in the number of Fos-immunoreactive nuclei. Interestingly, the infragranular layers displayed more Fos-immunoreactive neurons in experimental animals. This recruitment of an additional population of Fos expressing neurons in the subcortically projecting infragranular layers might have a protective function against neurodegeneration in the direct retinal target structures.
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Registered trials
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