ReviewCurrent opinion in pediatrics2010
Hypercalcemia in children and adolescents.
Review in Current opinion in pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 131 citations in OpenAlex.
- Pediatric inpatient hypercalcemia: triage using intact parathyroid hormone, age, and urinary calcium.World journal of pediatrics : WJP · 2026Article
- Admission ionised calcium disturbances and adverse outcomes in paediatric major trauma: a UK multicentre retrospective cohort study.BMJ open · 2026Article
- Comorbidities associated with early chronickidney disease among young people living withHIV in Uganda. A nested case control study.BMC nephrology · 2026Article
- Case Report: Two infants with hypercalcemia of rare and distinct etiologies.Frontiers in endocrinology · 2026Article
- An Important Physiological Concept in Therapeutics in Infantile Hypercalcemia.Indian journal of pediatrics · 2024Article
- Persistent mild hypercalcaemia in an infant with pseudohypoaldosteronism and the diagnostic challenges faced.Journal of nephrology · 2024Article
- Case 21-2024: A 10-Month-Old Boy with Vomiting and Hypercalcemia.The New England journal of medicine · 2024Article
- Atypical parathyroid adenoma with severe bone manifestations in early adolescence.BMJ case reports · 2024Article
- Symptomatic hypercalcemia in an infant secondary to excessive consumption of almond milk as a formula alternative.JPGN reports · 2024Article
- A Giant Parathyroid Adenoma Presenting as Nausea, Vomiting, and Headaches in an Adolescent Male.Case reports in pediatrics · 2023Article
- Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases.Nutrients · 2022Article
- Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals.Children (Basel, Switzerland) · 2022Article
- Genetic causes of neonatal and infantile hypercalcaemia.Pediatric nephrology (Berlin, Germany) · 2022Review
- Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism.Frontiers in endocrinology · 2022Review
- Hypercalcemia and Neurological Symptoms: A Rare Presentation of Hyperfunctioning Parathyroid Adenoma in an Adolescent.Frontiers in surgery · 2022Article
- Hypercalcemia associated with dysgerminoma and elevation of calcitriol: A case report and review of the literature.SAGE open medical case reports · 2022Article
- Article
- Severe hypercalcemia associated with hypophosphatemia in very premature infants: a case report.Italian journal of pediatrics · 2021Article
- A toddler with severe hypercalcemia and pyelonephritis: Answers.Pediatric nephrology (Berlin, Germany) · 2021Article
- Structural and chemical heterogeneities of primary hyperoxaluria kidney stones from pediatric patients.Journal of pediatric urology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
purpose of reviewIn this review, we define hypercalcemia levels, common causes for hypercalcemia in children, and treatment in order to aid the practicing pediatrician. RECENT
findingsOne rare cause of hypercalcemia in the child is familial hypocalciuric hypercalcemia (also termed familial benign hypercalcemia). Mutations that inactivate the Ca-sensing receptor gene FHH have been described as an autosomal dominant disorder, but recently milder mutations in the CASR have been shown to cause hypercalcemia when homozygous. SUMMARY: Normal serum levels of calcium are maintained through the interplay of parathyroid, renal, and skeletal factors. In this review, we have distinguished the neonate and infant from the older child and adolescent because the causes and clinical features of hypercalcemia can differ in these two age groups. However, the initial approach to the medical treatment of severe or symptomatic hypercalcemia is to increase the urinary excretion of calcium in both groups. In most cases, hypercalcemia is due to osteoclastic bone resorption, and agents that inhibit or destroy osteoclasts are, therefore, effective treatments. Parathyroid surgery, the conventional treatment for adults with symptomatic primary hyperparathyroidism, is recommended for all children with primary hyperparathyroidism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.