Trial reportJournal of tropical pediatrics2011
Morbidity and mortality among infants born to HIV-infected women in South Africa: implications for child health in resource-limited settings.
Trial report in Journal of tropical pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Mortality risk and associated factors in HIV-exposed, uninfected children.Tropical medicine & international health : TM & IH · 2016Pooled it
- Effects of postnatal interventions for the reduction of vertical HIV transmission on infant growth and non-HIV infections: a systematic review.Journal of the International AIDS Society · 2013Pooled it
- Infectious Morbidity, Mortality and Nutrition in HIV-exposed, Uninfected, Formula-fed Infants: Results From the HPTN 040/PACTG 1043 Trial.The Pediatric infectious disease journal · 2018Trial
- The aetiology of diarrhoea, pneumonia and respiratory colonization of HIV-exposed infants randomized to breast- or formula-feeding.Paediatrics and international child health · 2016Trial
- Health outcomes of HIV-exposed uninfected African infants.AIDS (London, England) · 2013Trial
- Early inflammation as a footprint of increased mortality risk in infants living with HIV from three African countries.Scientific reports · 2024Article
- Article
- Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon.Journal of immunology research · 2021Article
- Contribution of Maternal Antiretroviral Therapy and Breastfeeding to 24-Month Survival in Human Immunodeficiency Virus-Exposed Uninfected Children: An Individual Pooled Analysis of African and Asian Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Greater involvement of HIV-infected peer-mothers in provision of reproductive health services as "family planning champions" increases referrals and uptake of family planning among HIV-infected mothers.BMC health services research · 2017Article
- High Burden of Morbidity and Mortality but Not Growth Failure in Infants Exposed to but Uninfected with Human Immunodeficiency Virus in Tanzania.The Journal of pediatrics · 2017Article
- Breastfeeding Is Associated with Decreased Risk of Hospitalization among HIV-Exposed, Uninfected Kenyan Infants.Journal of human lactation : official journal of International Lactation Consultant Association · 2016Article
- Causes of mortality and associated modifiable health care factors for children (< 5-years) admitted at Onandjokwe Hospital, Namibia.African journal of primary health care & family medicine · 2015Article
- Current tuberculin reactivity of schoolchildren in the Central African Republic.BMC public health · 2015Article
- Impact of elevated maternal HIV viral load at delivery on T-cell populations in HIV exposed uninfected infants in Mozambique.BMC infectious diseases · 2015Article
- Breastfeeding is associated with decreased pneumonia incidence among HIV-exposed, uninfected Kenyan infants.AIDS (London, England) · 2013Article
- High rates of all-cause and gastroenteritis-related hospitalization morbidity and mortality among HIV-exposed Indian infants.BMC infectious diseases · 2011Article
- Post-HAART outcomes in pediatric populations: comparison of resource-limited and developed countries.Pediatrics · 2011Review
- Immunologic basis for revaccination of HIV-infected children receiving HAART.Future virology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWe examined correlates of infant morbidity and mortality within the first 3 months of life among HIV-exposed infants receiving post-exposure antiretroviral prophylaxis in South Africa.
methodsWe conducted a prospective cohort study of 848 mother-child dyads. Multivariable Cox proportional hazards models were used.
resultsThe main causes of infant morbidity were gastrointestinal and respiratory infections. Morbidity was higher with infant HIV infection (HR: 2.61; 95% CI: 1.40-4.85; p = 0.002) and maternal plasma viral load (PVL) >100,000 copies ml⁻¹ (HR: 1.87; 95% CI: 1.01-3.48; p = 0.048), and lower with maternal age < 20 years (HR: 0.25; 95% CI: 0.07-0.88; p = 0.031). Mortality was higher with infant HIV infection (HR: 4.10; 95% CI: 1.18-14.31; p = 0.027) and maternal PVL >100,000 copies ml⁻¹ (HR: 6.93; 95% CI: 1.64-29.26; p = 0.008). Infant feeding status did not influence the risk of morbidity nor mortality.
conclusionsFuture interventions that minimize pediatric HIV infection and reduce maternal viremia, which are the main predictors of child health soon after birth, will impact positively on infant health outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.