ReviewProceedings of the American Thoracic Society2010
Mitigation of chlorine lung injury by increasing cyclic AMP levels.
Review in Proceedings of the American Thoracic Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- The long road to Ithaca: a physiologist's journey.American journal of physiology. Cell physiology · 2025Review
- Article
- Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems.Physiology (Bethesda, Md.) · 2021Review
- Toxic effects of chlorine gas and potential treatments: a literature review.Toxicology mechanisms and methods · 2021Review
- Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets.Annals of the New York Academy of Sciences · 2020Article
- Disease-modifying treatment of chemical threat agent-induced acute lung injury.Annals of the New York Academy of Sciences · 2020Review
- Nitrite therapy prevents chlorine gas toxicity in rabbits.Toxicology letters · 2017Article
- Metabolomics Investigation Reveals Metabolite Mediators Associated with Acute Lung Injury and Repair in a Murine Model of Influenza Pneumonia.Scientific reports · 2016Article
- Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation.Toxicology and applied pharmacology · 2016Article
- Effect of dobutamine on lung aquaporin 5 in endotoxine shock-induced acute lung injury rabbit.Journal of thoracic disease · 2015Article
- Nitrite therapy improves survival postexposure to chlorine gas.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature.Toxicology · 2014Article
- Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction.Toxicology and applied pharmacology · 2014Article
- Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide.Toxicology and applied pharmacology · 2013Article
- Chlorine induces the unfolded protein response in murine lungs and skin.American journal of respiratory cell and molecular biology · 2013Article
- Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?Drug design, development and therapy · 2013Review
- Targeted aerosolized delivery of ascorbate in the lungs of chlorine-exposed rats.Journal of aerosol medicine and pulmonary drug delivery · 2012Article
- Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality.Free radical biology & medicine · 2012Article
- Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram.Toxicology and applied pharmacology · 2012Article
- Integrative assessment of chlorine-induced acute lung injury in mice.American journal of respiratory cell and molecular biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Chlorine is considered a chemical threat agent to which humans may be exposed as a result of accidental or intentional release. Chlorine is highly reactive, and inhalation of the gas causes cellular damage to the respiratory tract, inflammation, pulmonary edema, and airway hyperreactivity. Drugs that increase intracellular levels of the signaling molecule cyclic AMP (cAMP) may be useful for treatment of acute lung injury through effects on alveolar fluid clearance, inflammation, and airway reactivity. This article describes mechanisms by which cAMP regulates cellular processes affecting lung injury and discusses the basis for investigating drugs that increase cAMP levels as potential treatments for chlorine-induced lung injury. The effects of beta(2)-adrenergic agonists, which stimulate cAMP synthesis, and phosphodiesterase inhibitors, which inhibit cAMP degradation, on acute lung injury are reviewed, and the relative advantages of these approaches are compared.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.