ArticleJournal of immunology (Baltimore, Md. : 1950)2010
T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Exploring Localized Provoked Vulvodynia: Insights from Animal Model Research.International journal of molecular sciences · 2024Pooled it
- Immune mechanisms in vulvodynia: key roles for mast cells and fibroblasts.Frontiers in cellular and infection microbiology · 2023Review
- Inflammation and tumor progression: signaling pathways and targeted intervention.Signal transduction and targeted therapy · 2021Article
- Article
- Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation and Persistent Tactile Sensitivity in Mouse Model of Allergen-Provoked Localized Vulvodynia.International journal of molecular sciences · 2019Article
- Mast cell degranulation impairs pneumococcus clearance in miceThe World Allergy Organization journal · 2019Article
- Therapeutic vaccines for allergic disease.NPJ vaccines · 2017Article
- Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia.PloS one · 2017Article
- Transfer of regulatory T cells into abortion-prone mice promotes the expansion of uterine mast cells and normalizes early pregnancy angiogenesis.Scientific reports · 2015Article
- Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer.Molecular immunology · 2015Review
- Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains.Allergy · 2013Article
- Regulatory T cells enhance mast cell production of IL-6 via surface-bound TGF-β.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In C57BL/6 mice, the recruitment of mast cell progenitors (MCps) to the lung is a feature of Ag-induced pulmonary inflammation that requires sensitization and challenge and is totally inhibited by the administration of anti-CD4 at the time of challenge. When mAb to TGFbeta1 or to IL-10R was administered at the time of challenge, the recruitment of MCp/10(6) mononuclear cells (MNCs) to the lung was inhibited by 56.3 and 69.6%, respectively, whereas mAb to IL-4, IFN-gamma, IL-6, IL-17A, and IL-17F had no effect. In sensitized and challenged C57BL/6 mice lacking TGFbetaRII on CD4(+) cells, the recruitment of MCp/10(6) MNCs was reduced by 67.8%. The requirement for TGFbeta1 and IL-10 suggested a role for CD4(+)CD25(+) T regulatory cells. Mice treated with anti-CD25 at the time of Ag-challenge showed a reduction in the recruitment of MCp/10(6) MNCs by 77.2% without any reduction in MNC influx. These results reveal an unexpected role for T regulatory cells in promoting the recruitment of MCps to the lungs of C57BL/6 mice with Ag-induced pulmonary inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.