ArticleGenome research2010
Fragile regions and not functional constraints predominate in shaping gene organization in the genus Drosophila.
Article in Genome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
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- Fundamental Patterns of Structural Evolution Revealed by Chromosome-Length Genomes of Cactophilic Drosophila.Genome biology and evolution · 2024Article
- Article
- Multiscale analysis of the randomization limits of the chromosomal gene organization between Lepidoptera and Diptera.Proceedings. Biological sciences · 2022Article
- Genus-Wide Characterization of Bumblebee Genomes Provides Insights into Their Evolution and Variation in Ecological and Behavioral Traits.Molecular biology and evolution · 2021Article
- The molecular genealogy of sequential overlapping inversions implies both homologous chromosomes of a heterokaryotype in an inversion origin.Scientific reports · 2019Article
- Inversions are bigger on the X chromosome.Molecular ecology · 2019Article
- The molecular characterization of fixed inversions breakpoints unveils the ancestral character of the Drosophila guanche chromosomal arrangements.Scientific reports · 2019Article
- Local adaptation and the evolution of inversions on sex chromosomes and autosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Muller "Elements" inGenetics · 2018Article
- Inversion evolutionary rates might limit the experimental identification of inversion breakpoints in non-model species.Scientific reports · 2017Article
- Dense gene physical maps of the non-model species Drosophila subobscura.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Article
- Multiple and diverse structural changes affect the breakpoint regions of polymorphic inversions across the Drosophila genus.Scientific reports · 2016Article
- The origin of chromosomal inversions as a source of segmental duplications in the Sophophora subgenus of Drosophila.Scientific reports · 2016Article
- Article
- A molecular perspective on a complex polymorphic inversion system with cytological evidence of multiply reused breakpoints.Heredity · 2015Article
- Quantified effects of chromosome-nuclear envelope attachments on 3D organization of chromosomes.Nucleus (Austin, Tex.) · 2015Article
- DNA copy number evolution in Drosophila cell lines.Genome biology · 2014Article
- Underreplicated regions in Drosophila melanogaster are enriched with fast-evolving genes and highly conserved noncoding sequences.Genome biology and evolution · 2014Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
During evolution, gene repatterning across eukaryotic genomes is not uniform. Some genomic regions exhibit a gene organization conserved phylogenetically, while others are recurrently involved in chromosomal rearrangement, resulting in breakpoint reuse. Both gene order conservation and breakpoint reuse can result from the existence of functional constraints on where chromosomal breakpoints occur or from the existence of regions that are susceptible to breakage. The balance between these two mechanisms is still poorly understood. Drosophila species have very dynamic genomes and, therefore, can be very informative. We compared the gene organization of the main five chromosomal elements (Muller's elements A-E) of nine Drosophila species. Under a parsimonious evolutionary scenario, we estimate that 6116 breakpoints differentiate the gene orders of the species and that breakpoint reuse is associated with approximately 80% of the orthologous landmarks. The comparison of the observed patterns of change in gene organization with those predicted under different simulated modes of evolution shows that fragile regions alone can explain the observed key patterns of Muller's element A (X chromosome) more often than for any other Muller's element. High levels of fragility plus constraints operating on approximately 15% of the genome are sufficient to explain the observed patterns of change and conservation across species. The orthologous landmarks more likely to be under constraint exhibit both a remarkable internal functional heterogeneity and a lack of common functional themes with the exception of the presence of highly conserved noncoding elements. Fragile regions rather than functional constraints have been the main determinant of the evolution of the Drosophila chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.