ReviewRespiratory physiology & neurobiology2010
ATP, glia and central respiratory control.
Review in Respiratory physiology & neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- Review
- Astrocyte activation in the ventrolateral medulla modulates breathing and arousal states.Nature communications · 2026Article
- Neonatal inflammation induces lasting sex- and region-dependent microglia activation and sex-dependent impairments in chemoreflexes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Update on vascular control of central chemoreceptors.Experimental physiology · 2024Review
- Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders.International journal of molecular sciences · 2024Review
- The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System.Current neuropharmacology · 2024Review
- Contributions of carotid bodies, retrotrapezoid nucleus neurons and preBötzinger complex astrocytes to the COThe Journal of physiology · 2024Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- Review: Neuropathology findings in autonomic brain regions in SUDEP and future research directions.Autonomic neuroscience : basic & clinical · 2021Review
- The retrotrapezoid nucleus and the neuromodulation of breathing.Journal of neurophysiology · 2021Review
- Thrombin action on astrocytes in the hindbrain of the rat disrupts glycemic and respiratory control.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Evidence that hindbrain astrocytes in the rat detect low glucose with a glucose transporter 2-phospholipase C-calcium release mechanism.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Hindbrain astrocytes and glucose counter-regulation.Physiology & behavior · 2019Review
- Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.The Journal of physiology · 2018Review
- Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression.CNS neuroscience & therapeutics · 2018Article
- Glial Cells Are Involved in ANG-II-Induced Vasopressin Release and Sodium Intake in Awake Rats.Frontiers in physiology · 2018Article
- ATP and astrocytes play a prominent role in the control of the respiratory pattern generator in the lamprey.The Journal of physiology · 2017Article
- Article
- Fluorocitrate-mediated depolarization of astrocytes in the retrotrapezoid nucleus stimulates breathing.Journal of neurophysiology · 2017Article
- Minocycline blocks glial cell activation and ventilatory acclimatization to hypoxia.Journal of neurophysiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
An increase in PCO(2) in the arterial blood triggers immediate release of ATP from the ventral chemosensory site(s) on the surface of the medulla oblongata. Systemic hypoxia in anesthetized rats was also associated with increased ATP release on the ventral medullary surface. During both hypoxia and hypercapnia, ATP and possibly other gliotransmitters released in the ventral medulla seemed to enhance cardiorespiratory responses to these stressors, and some of this ATP was proposed to be derived from astrocytes. Astrocytes also play a vital role controlling local blood flow. Astrocytes are activated by neurotransmitter release - especially glutamate and ATP. The astrocytic activation is manifest as a rise in intracellular Ca(2+) that is closely coupled to the metabolic activity of neurons in the active area. The activation of astrocytes spreads as a wave from astrocyte to astrocyte and causes release of ATP, adenosine, and other gliotransmitters that may alter neuronal function in the region of astrocytic activation. In addition, ATP, adenosine and other vasoactive substances, when released at the endfeet of astrocytes, interact with vascular receptors that may either dilate or constrict the vessels in the region closely adjacent to the site of neuronal activity. Thus, astrocytes seem to integrate neuronal metabolic needs by responding to the level of neuronal activity to regulate local blood flow and cardiorespiratory responses to hypoxia and hypercapnia to match substrate need (oxygen and glucose) with substrate availability and with the removal of CO(2). In so doing, astrocytes assume a larger role in information processing and in the regulation of neuronal activity and homeostasis of the entire organism than has been ascribed to them in the past.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.