ArticleNeurotoxicology and teratology
Prenatal cocaine exposure: Effects on mother- and teacher-rated behavior problems and growth in school-age children.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Systematic Review and Meta-analysis of the Relationship Between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- From Distress To Disruption in Early Childhood: Time-Varying Associations Between Internalizing and Externalizing Problems, Child Sex and Prenatal Cocaine Exposure.Research on child and adolescent psychopathology · 2025Article
- Prenatal Cocaine Exposure, Perinatal Risks, and Mediators to Preadolescent Attention Deficit Hyperactivity Disorder (ADHD).Children (Basel, Switzerland) · 2025Article
- Effects of Fetal Substance Exposure on Offspring Substance Use.Pediatric clinics of North America · 2019Review
- Prenatal cocaine exposure: Direct and indirect associations with 21-year-old offspring substance use and behavior problems.Drug and alcohol dependence · 2019Article
- Testing the programming of temperament and psychopathology in two independent samples of children with prenatal substance exposure.Development and psychopathology · 2018Article
- Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders.Birth defects research · 2017Review
- The association of prenatal cocaine exposure, externalizing behavior and adolescent substance use.Drug and alcohol dependence · 2017Article
- School-Aged Outcomes following Prenatal Methamphetamine Exposure: 7.5-Year Follow-Up from the Infant Development, Environment, and Lifestyle Study.The Journal of pediatrics · 2016Article
- Parental Substance Abuse As an Early Traumatic Event. Preliminary Findings on Neuropsychological and Personality Functioning in Young Drug Addicts Exposed to Drugs Early.Frontiers in psychology · 2016Article
- Prenatal substance exposure: What predicts behavioral resilience by early adolescence?Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2015Article
- Prenatal cocaine exposure and age of sexual initiation: direct and indirect effects.Drug and alcohol dependence · 2014Article
- Externalizing behavior and substance use related problems at 15 years in prenatally cocaine exposed adolescents.Journal of adolescence · 2014Article
- Comparison of 12-year-old children with prenatal exposure to cocaine and non-exposed controls on caregiver ratings of executive function.Journal of youth and adolescence · 2014Article
- Externalizing problems in late childhood as a function of prenatal cocaine exposure and environmental risk.Journal of pediatric psychology · 2013Article
- Adolescent initiation of drug use: effects of prenatal cocaine exposure.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Article
- Protective factors can mitigate behavior problems after prenatal cocaine and other drug exposures.Pediatrics · 2012Article
- Developmental and behavioral consequences of prenatal cocaine exposure: a review.Journal of perinatology : official journal of the California Perinatal Association · 2012Review
- Prenatal methamphetamine exposure and childhood behavior problems at 3 and 5 years of age.Pediatrics · 2012Article
- Fetal Growth Outcomes in a Cohort of Polydrug- and Opioid-Dependent Patients.The Journal of reproductive medicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In this longitudinal study of prenatal cocaine exposure (PCE), school-age physical and cognitive development and behavioral characteristics were examined, while controlling for other factors that affect child development. At this follow-up phase, children were on average 7.2 years old, and their caregivers were 33.7 years old, had 12.5 years of education, and 48% were African American. During the first trimester, 20% of the women were frequent cocaine users (≥1 line/day). First trimester cocaine exposure predicted decreased weight and height at 7 years. There was no significant relationship between PCE and the cognitive and neuropsychological measures. Third trimester cocaine use predicted more total and externalizing behavior problems on the Child Behavior Checklist (Achenbach, 1991 [3]) and the Teacher Report Form (Achenbach, 1991 [4]), and increased activity, inattention, and impulsivity on the Routh Activity (Routh et al., 1974 [67]) and SNAP scales (Pelham and Bender, 1982 [55]). Children who were exposed to cocaine throughout pregnancy had more mother- and teacher-rated behavior problems compared to children of women who stopped using early in pregnancy or who never used cocaine prenatally. These detrimental effects of PCE on behavior are consistent with other reports in the literature and with the hypothesis that PCE affects development through changes in neurotransmitter systems. These school-age behaviors may be precursors of later adolescent behavior problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.