ArticleBrain, behavior, and immunity2010
Essential role of interleukin-15 receptor in normal anxiety behavior.
Article in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- IL-15 receptor alpha deficiency triggers depressive-like behaviors via enhanced microglial synapse pruning.Molecular psychiatry · 2026Article
- The causal association between 91 inflammatory Circulating proteins and intracerebral hemorrhage: A bidirectional two-sample Mendelian randomization study.Neurosurgical review · 2025Article
- Single-cell transcriptome of mouse hippocampus identifies neural precursor-like cells, and reveals IL15Rα knock out-mediated neuron remodeling.BMC genomics · 2025Article
- Proteomic Biomarkers as Mediators in the Association Between Air Pollution and Incident Depression and Anxiety: Evidence From the UK Biobank.Depression and anxiety · 2025Article
- Remodeling p38 signaling in muscle controls locomotor activity via IL-15.Science advances · 2024Article
- Interleukin 15 modulates the effects of poly I:C maternal immune activation on offspring behaviour.Brain, behavior, & immunity - health · 2022Article
- Reduced Serum Levels of Soluble Interleukin-15 Receptor α in Schizophrenia and Its Relationship to the Excited Phenotype.Frontiers in psychiatry · 2022Article
- Blood cytokines differentiate bipolar disorder and major depressive disorder during a major depressive episode: Initial discovery and independent sample replication.Brain, behavior, & immunity - health · 2021Article
- Skeletal Muscle O-GlcNAc Transferase Action on Global Metabolism Is Partially Mediated Through Interleukin-15.Frontiers in physiology · 2021Article
- Immune activity at birth and later psychopathology in childhood.Brain, behavior, & immunity - health · 2020Article
- Phenotypic Resemblance to Neuropsychiatric Disorder and Altered mRNA Profiles in Cortex and Hippocampus UnderlyingFrontiers in neuroscience · 2020Article
- Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated byFrontiers in physiology · 2019Article
- Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA.Journal of cell science · 2018Article
- A genetic variant in IL-15Rα correlates with physical activity among European-American adults.Molecular genetics & genomic medicine · 2018Article
- Connecting Myokines and Metabolism.Endocrinology and metabolism (Seoul, Korea) · 2015Review
- IL-15 receptor α signaling constrains the development of IL-17-producing γδ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Sleep fragmentation has differential effects on obese and lean mice.Journal of molecular neuroscience : MN · 2015Article
- Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system.Frontiers in microbiology · 2015Article
- Assessment of murine exercise endurance without the use of a shock grid: an alternative to forced exercise.Journal of visualized experiments : JoVE · 2014Article
- Hypersomnolence and reduced activity in pan-leptin receptor knockout mice.Journal of molecular neuroscience : MN · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The interactions between the cytokine interleukin (IL)-15 and the classical neurotransmitter GABA have been shown in IL15Rα receptor knockout mice by observations of memory deficits and reduction of GABA. To test the hypothesis that IL15 affects anxiety-like behavior, knockout mice without IL15, IL15Rα, or the co-receptor IL2Rγ were subjected to open-field and elevated plus maze tests. All three strains showed reduction of anxiety, with greater changes in the IL15Rα knockout mice than in the IL15 or IL2Rγ knockout mice. This unexpected observation is opposite to the reported increase of anxiety in mice lacking other proinflammatory cytokines or their receptors. The reduced anxiety was not associated with changes in associated serum cytokines. However, Western blotting, qPCR, and immunohistochemistry all showed that IL15Rα knockout mice had mild microgliosis and astrogliosis in the hippocampus. To determine whether this gliosis plays a role in decreasing anxiety, IL15Rα knockout mice were treated with minocycline, but this did not cause a change in open field performance. To determine whether IL15 plays a direct role in anxiety, wildtype mice were treated with IL15 by intraperitoneal injection. This also failed to cause a change in open field behavior under the experimental conditions tested. Thus, IL15Rα is essential for normal anxiety-like behavior, but inhibition of gliosis in the fearless IL15Rα knockout mice or IL15 treatment of normal mice did not acutely modulate behavioral performance as tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.