Trial reportBrain, behavior, and immunity2010
Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach.
Trial report in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quality of Life Interventions During Cervical Cancer Treatment
The Effect of Touch on Pain and Anxiety During the Bone Marrow Biopsy Procedure
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Bioenergy therapies as a complementary treatment: a systematic review to evaluate the efficacy of bioenergy therapies in relieving treatment toxicities in patients with cancer.Journal of cancer research and clinical oncology · 2023Pooled it
- Relationship between social support, quality of life, and Th2 cytokines in a biobehavioral cancer survivorship trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Trial
- Metabolic Effects of Healing Touch During Cervical Cancer Treatment: An Exploratory Analysis.Integrative cancer therapiesTrial
- Exploring the mechanisms of biofield therapy through joint electrophysiological recordings in humans and mice.IBRO neuroscience reports · 2026Article
- The Preclinical Effects and Mechanisms of Biofield Therapy on Pancreatic Cancer Cell Growth and Metastasis.Cancer medicine · 2026Article
- Integrative options for the management of anxiety and depression in people with cancer.Frontiers in oncology · 2026Review
- Exploring prehabilitation interventions for patients with gynaecological cancer undergoing radiotherapy: A scoping review.PloS one · 2025Article
- Examining the effects of biofield therapy through simultaneous assessment of electrophysiological and cellular outcomes.Scientific reports · 2024Article
- Brachytherapy for targeting the immune system in cervical cancer patients.BMC immunology · 2023Article
- Perspectives, Measurability and Effects of Non-Contact Biofield-Based Practices: A Narrative Review of Quantitative Research.International journal of environmental research and public health · 2021Review
- The impact of psychosocial stress and stress management on immune responses in patients with cancer.Cancer · 2019Review
- Review
- Effect of Therapeutic Touch in Patients with Cancer: a Literature Review.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Review
- Bioenergy and Breast Cancer: A Report on Tumor Growth and Metastasis.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Designing a broad-spectrum integrative approach for cancer prevention and treatment.Seminars in cancer biology · 2015Review
- Biofield Science and Healing: History, Terminology, and Concepts.Global advances in health and medicine · 2015Article
- Challenges for Preclinical Investigations of Human Biofield Modalities.Global advances in health and medicine · 2015Review
- Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations.Global advances in health and medicine · 2015Article
- Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Hepatoma-derived growth factor upregulation is correlated with prognostic factors of early-stage cervical adenocarcinoma.International journal of molecular sciences · 2014Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Patients receiving chemoradiation for cervical cancer are at risk for distress, chemoradiation-related side-effects, and immunosuppression. This prospective randomized clinical trial examined effects of a complementary therapy, Healing Touch (HT), versus relaxation training (RT) and usual care (UC) for (1) supporting cellular immunity, (2) improving mood and quality of life (QOL), and (3) reducing treatment-associated toxicities and treatment delay in cervical cancer patients receiving chemoradiation. Sixty women with stages IB1 to IVA cervical cancer were randomly assigned to receive UC or 4 ×/weekly individual sessions of either HT or RT immediately following radiation during their 6-week chemoradiation treatment. Patients completed psychosocial assessments and blood sampling before chemoradiation at baseline, weeks 4 and 6. Multilevel regression analyses using orthogonal contrasts tested for differences between treatment conditions over time. HT patients had a minimal decrease in natural killer cell cytotoxicity (NKCC) over the course of treatment whereas NKCC of RT and UC patients declined sharply during chemoradiation (group by time interaction: p = 0.018). HT patients showed greater decreases in two different indicators of depressed mood (CES-D depressed mood subscale and POMS depression scale) compared to RT and UC (group by time interactions: p<0.05). No between group differences were observed in QOL, treatment delay, or clinically-rated toxicities. HT may benefit cervical cancer patients by moderating effects of chemoradiation on depressed mood and cellular immunity. Effects of HT on toxicities, treatment delay, QOL, and fatigue were not observed. Long-term clinical implications of findings are not known.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.